Reassessment of oxidative stress in idiopathic sudden hearing loss and preliminary exploration of the effect of physiological concentration of melatonin on prognosis

Frontiers in Neurology

Neurology

Fang Ouyang¹  Li Fan²  Zhiyuan Zhang²  Qing Luo²  Yuanping Xiong²  Jianxiong Song²  Hongqun Jiang² 

[1] Department of Endocrinology, The First Affiliated Hospital of Nanchang University, Nanchang, China;Department of Otolaryngology, The First Affiliated Hospital of Nanchang University, Nanchang, China;

关键词: idiopathic sudden sensorineural hearing loss;    reactive oxygen species;    melatonin;    total antioxidant capacity;    oxidative stress;   

DOI  :  10.3389/fneur.2023.1249312

 received in 2023-06-28, accepted in 2023-08-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

Background and purposeThe pathogenesis of idiopathic sudden sensorineural hearing loss (ISSNHL) is still unclear, and there is no targeted treatment. This research aimed to verify the role of oxidative stress in ISSNHL and explore whether melatonin has a protective effect on hearing.Materials and methodsA total of 43 patients with ISSNHL and 15 healthy controls were recruited to detect the level of melatonin, reactive oxygen species (ROS), and total antioxidant capacity (TAC) in the blood and compared before and after treatment. Multivariate logistic regression models were performed to assess the factors relevant to the occurrence and improvement of ISSNHL.ResultsThe patients with ISSNHL showed significantly higher ROS levels than controls (4.42 ± 4.40 vs. 2.30 ± 0.59; p = 0.031). The levels of basal melatonin were higher (1400.83 ± 784.89 vs. 1095.97 ± 689.08; p = 0.046) and ROS levels were lower (3.05 ± 1.81 vs. 5.62 ± 5.56; p = 0.042) in the effective group as compared with the ineffective group. Logistic regression analysis showed that melatonin (OR = 0.999, 95% CI 0.997–1.000, p = 0.049), ROS (OR = 1.154, 95% CI 1.025–2.236, p = 0.037), and vertigo (OR = 3.011, 95% CI 1.339–26.983, p = 0.019) were independent factors associated with hearing improvement. Besides, the level of melatonin (OR = 0.999, 95% CI 0.998–1.000, p = 0.023) and ROS (OR = 3.248, 95% CI 1.109–9.516, p = 0.032) were associated with the occurrence of ISSNHL.ConclusionOur findings may suggest oxidative stress involvement in ISSNHL etiopathogenesis. The level of melatonin and ROS, and vertigo appear to be predictive of the effectiveness of hearing improvement following ISSNHL treatment.

【 授权许可】

Unknown   
Copyright © 2023 Song, Ouyang, Xiong, Luo, Jiang, Fan and Zhang.