Circadian, hormonal, and sleep rhythms: effects on cancer progression implications for treatment

Frontiers in Oncology

Oncology

Catherine Benedict¹  David Spiegel¹  Annemarie D. Jagielo² 

[1] Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, CA, Stanford, CA, United States;PGSP-Stanford Psy.D. Consortium, Palo Alto University, Palo Alto, CA, United States;Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, CA, Stanford, CA, United States;

关键词: circadian rhythms;    cancer;    sleep disturbance;    cortisol;    chronotherapeutics;   

DOI  :  10.3389/fonc.2023.1269378

 received in 2023-07-29, accepted in 2023-08-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

Circadian, hormonal, and sleep rhythm disruptions are commonly experienced concerns among cancer patients throughout the cancer care continuum. This review aims to summarize the existing literature on circadian, hormonal, and sleep rhythms in the oncological population, focusing on circadian disruption and physiological and psychological abnormalities, disease progression, and chronomodulated treatment approaches. The findings demonstrate that subjectively and objectively measured circadian rhythm disruption is associated with adverse mental health and disease outcomes in patients with cancer. Chronomodulated chemotherapy, light therapy, cognitive behavioral therapy for insomnia, and physical activity have shown evidence of effectiveness in improving sleep, and occasionally, disease outcomes.

【 授权许可】

Unknown   
Copyright © 2023 Jagielo, Benedict and Spiegel