Utility of a simplified [18F] sodium fluoride PET imaging method to quantify bone metabolic flux for a wide range of clinical applications

Frontiers in Endocrinology

Endocrinology

Claire Fynbo¹  James Wong²  Glen M. Blake³  Gary J. R. Cook⁴  Amelia E. B. Moore⁴  Jørn Theil⁵  Kalevi Kairemo⁶  Thomas J. Werner⁷  Abass Alavi⁷  Ananya Choudhury⁸  Tanuj Puri⁹  Habib Zaidi^1,10  Michelle L. Frost^1,11  Sobhan Vinjamuri^1,12  Abhishek Mahajan^1,13  Mona-Elisabeth Revheim^1,14  Marie Vrist^1,15 

[1] Clinic of Nuclear Medicine, Gødstrup Hospital, Herning, Denmark;Department of Anaesthesia, St Bartholomew’s Hospital, Barts Health NHS Trust, London, United Kingdom;Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King’s College London, St. Thomas’ Hospital, London, United Kingdom;Department of Cancer Imaging, and King’s College London and Guy’s and St Thomas’ PET Centre, School of Biomedical Engineering and Imaging Sciences, King’s College London, St. Thomas’ Hospital, London, United Kingdom;Department of Clinical Medicine, Aarhus University, Aarhus, Denmark;Department of Nuclear Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States;Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, United States;Faculty of Biology, Medicine and Health, School of Medical Sciences, Division of Cancer Sciences, The University of Manchester, The Christie NHS Foundation Trust, Manchester, United Kingdom;Faculty of Biology, Medicine and Health, School of Medical Sciences, Division of Cancer Sciences, The University of Manchester, The Christie NHS Foundation Trust, Manchester, United Kingdom;Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King’s College London, St. Thomas’ Hospital, London, United Kingdom;Geneva University Hospital, Division of Nuclear Medicine and Molecular Imaging, Geneva, Switzerland;Institute of Cancer Research Clinical Trials & Statistics Unit (ICR-CTSU), The Institute of Cancer Research, Sutton, United Kingdom;Nuclear Medicine Department, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, United Kingdom;The Clatterbridge Cancer Centre NHS Foundation Trust, University of Liverpool, Liverpool, United Kingdom;The Intervention Centre, Oslo University Hospital, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway;University Clinic in Nephrology and Hypertension, Gødstrup Hospital, Herning, Denmark;

关键词: quantitative measurement of bone;    bone metabolic flux;    clinical applications;    future developments;    [F]NaF;    K;    PET-CT;    [F] sodium fluoride;   

DOI  :  10.3389/fendo.2023.1236881

 received in 2023-06-08, accepted in 2023-08-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

We review the rationale, methodology, and clinical utility of quantitative [18F] sodium fluoride ([18F]NaF) positron emission tomography-computed tomography (PET-CT) imaging to measure bone metabolic flux (Ki, also known as bone plasma clearance), a measurement indicative of the local rate of bone formation at the chosen region of interest. We review the bone remodelling cycle and explain what aspects of bone remodelling are addressed by [18F]NaF PET-CT. We explain how the technique works, what measurements are involved, and what makes [18F]NaF PET-CT a useful tool for the study of bone remodelling. We discuss how these measurements can be simplified without loss of accuracy to make the technique more accessible. Finally, we briefly review some key clinical applications and discuss the potential for future developments. We hope that the simplified method described here will assist in promoting the wider use of the technique.

【 授权许可】

Unknown   
Copyright © 2023 Puri, Frost, Moore, Choudhury, Vinjamuri, Mahajan, Fynbo, Vrist, Theil, Kairemo, Wong, Zaidi, Revheim, Werner, Alavi, Cook and Blake