Recent advances in the study of anesthesia-and analgesia-related mechanisms of S-ketamine

Frontiers in Pharmacology

Pharmacology

Jun-ming Ye¹  Wei-dong Liang¹  Mao-lin Zhong¹  Yun-ling Deng¹  Li-feng Wang¹  Bing-yu Wang²  Zhen Chen²  Ming-ling Guo²  Ying-ying Liu²  Guan-fa Peng²  Jian-shun Zhou² 

[1] Department of Anesthesiology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China;Ganzhou Key Laboratory of Anesthesiology, Ganzhou, China;The First Clinical Medical College of Gannan Medical University, Ganzhou, China;

关键词: S-ketamine;    NMDA;    ketamine;    anesthesia;    analgesia;    AMPA;    opioid receptor;   

DOI  :  10.3389/fphar.2023.1228895

 received in 2023-05-25, accepted in 2023-09-04,  发布年份 2023

来源: Frontiers

【 摘 要 】

Ketamine is a racemic mixture of equal amounts of R-ketamine and S-ketamine and is well known to anesthesiologists for its unique dissociative anesthetic properties. The pharmacological properties of ketamine, namely, its sympathetic excitation, mild respiratory depression, and potent analgesia, are still highly valued in its use as an anesthetic for some patients. In particular, since its advent, S-ketamine has been widely used as an anesthetic in many countries due to its increased affinity for NMDA receptors and its enhanced anesthetic and analgesic effects. However, the anesthetic and analgesic mechanisms of S-ketamine are not fully understood. In addition to antagonizing NMDA receptors, a variety of other receptors or channels may be involved, but there are no relevant mechanistic summaries in the literature. Therefore, the purpose of this paper is to review the mechanisms of action of S-ketamine on relevant receptors and systems in the body that result in its pharmacological properties, such as anesthesia and analgesia, with the aim of providing a reference for its clinical applications and research.

【 授权许可】

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Copyright © 2023 Zhou, Peng, Liang, Chen, Liu, Wang, Guo, Deng, Ye, Zhong and Wang.