Metabolite profiling of peripheral blood plasma in pigs in early postnatal life fed whole bovine, caprine or ovine milk

Frontiers in Nutrition

Nutrition

Ryan N. Dilger¹  Debashree Roy²  Carlos A. Montoya³  Karl Fraser⁴  Wayne Young⁴  Jane A. Mullaney⁴  Caroline Giezenaar⁵  Warren C. McNabb⁶  Nicole C. Roy⁷  Ankita Jena⁸ 

[1] Department of Animal Sciences, University of Illinois, Urbana, IL, United States;Riddet Institute, Massey University, Palmerston North, New Zealand;Riddet Institute, Massey University, Palmerston North, New Zealand;AgResearch, Palmerston North, New Zealand;Riddet Institute, Massey University, Palmerston North, New Zealand;AgResearch, Palmerston North, New Zealand;High-Value Nutrition National Science Challenge, Auckland, New Zealand;Riddet Institute, Massey University, Palmerston North, New Zealand;Food Experience and Sensory Testing (FEAST) Laboratory, School of Food and Advanced Technology, Massey University, Palmerston North, New Zealand;Riddet Institute, Massey University, Palmerston North, New Zealand;High-Value Nutrition National Science Challenge, Auckland, New Zealand;Riddet Institute, Massey University, Palmerston North, New Zealand;High-Value Nutrition National Science Challenge, Auckland, New Zealand;Department of Human Nutrition, University of Otago, Dunedin, New Zealand;Riddet Institute, Massey University, Palmerston North, New Zealand;School of Food and Advanced Technology, College of Sciences, Massey University, Palmerston North, New Zealand;AgResearch, Palmerston North, New Zealand;

关键词: metabolomics;    early life;    nutrition;    ruminant milk;    pigs;    plasma;    infant;    lipids;   

DOI  :  10.3389/fnut.2023.1242301

 received in 2023-06-19, accepted in 2023-09-13,  发布年份 2023

来源: Frontiers

【 摘 要 】

Ruminants’ milk is commonly used for supplying nutrients to infants when breast milk is unavailable or limited. Previous studies have highlighted the differences between ruminants’ milk composition, digestion, absorption, and fermentation. However, whether consuming different ruminants’ milk impact the appearance of the circulatory blood metabolites in the early postnatal life is not well understood. The analysis conducted here aimed to determine the effect of feeding exclusively whole milk from bovine, caprine or ovine species to pigs, approximately 7 days-old for 15 days, on circulatory blood plasma metabolites. Relative intensities of plasma metabolites were detected using a liquid chromatography-mass spectrometry based metabolomic approach. Seven polar and 83 non-polar (lipids) metabolites in plasma were significantly different (false discovery rate < 0.05) between milk treatments. These included polar metabolites involved in amino acid metabolism and lipids belonging to phosphatidylcholine, lysophosphatidylcholine, sphingomyelin, and triglycerides. Compared to the caprine or bovine milk group, the relative intensities of polar metabolites and unsaturated triglycerides were higher in the peripheral circulation of the ovine milk group. In contrast, relative intensities of saturated triglycerides and phosphatidylcholine were higher in the bovine milk group compared to the ovine or caprine milk group. In addition, correlations were identified between amino acid and lipid intake and their appearance in peripheral blood circulation. The results highlighted that consuming different ruminants’ milk influences the plasma appearance of metabolites, especially lipids, that may contribute to early postnatal life development in pigs.

【 授权许可】

Unknown   
Copyright © 2023 Jena, Montoya, Fraser, Giezenaar, Young, Mullaney, Dilger, Roy, McNabb and Roy.