Beyond liver cancer, more application scenarios for alpha-fetoprotein in clinical practice

Frontiers in Oncology

Oncology

Yuhan Wang¹  Jiexin Zhang²  Huaguo Xu²  Chenyu Ma²  Yuexinzi Jin² 

[1] Center of Smart Laboratory and Molecular Medicine, School of Medicine, Chongqing University, Chongqing, China;Department of Laboratory Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China;

关键词: alpha-fetoprotein;    clinical application;    tumor;    pregnancy;    fetal diseases;   

DOI  :  10.3389/fonc.2023.1231420

 received in 2023-05-30, accepted in 2023-08-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

Alpha-fetoprotein (AFP) is a commonly used clinical biomarker. Before 1970, the two-way agar diffusion method was mainly used, and the specificity of AFP in the diagnosis of primary liver cancer was satisfactory. However, its positivity rate was not very high. The diagnostic value of AFP is changing with the evolution of detection methods. Here, we performed a literature search to identify English-language publications. The search was performed from January 2015 to April 2023 using the PubMed database and the following terms in [Titles/Abstracts]: alpha-fetoprotein, clinical practice, detection, etc. The references of retrieved articles were also screened to broaden the search. Studies referring to liver cancer and AFP detection methods were excluded. In this review, several clinical application scenarios for AFP were systematically reviewed, and its potential detection value in the future was discussed.

【 授权许可】

Unknown   
Copyright © 2023 Ma, Jin, Wang, Xu and Zhang