Severe neonatal enterovirus infection in twins with different outcomes: A case report

Frontiers in Pediatrics

Pediatrics

Tim Hundscheid¹  Leo Torn²  Herbert M. van Wering²  Daan De Herdt³  Kelly K. Storm⁴  Karen Couderé⁵  Jaco J. Verweij⁵ 

[1] Department of Neonatology, Amalia Children’s Hospital, Radboud University Medical Center, Nijmegen, Netherlands;Department of Pediatrics, Amphia Hospital, Breda, Netherlands;Department of Pediatrics, Amphia Hospital, Breda, Netherlands;Department of Pediatrics, Antwerp University Hospital, Edegem, Belgium;Department of Pediatrics, Amphia Hospital, Breda, Netherlands;Division of Neonatology, Department of Neonatal and Pediatric Intensive Care, Sophia Children's Hospital, Erasmus University Medical Center, Rotterdam, Netherlands;Microvida, Laboratory of Medical Microbiology and Immunology, Elisabeth-TweeSteden Hospital, Tilburg, Netherlands;

关键词: neonatology;    enterovirus;    sepsis;    myocarditis;    ECMO;    twins;   

DOI  :  10.3389/fped.2023.1181698

 received in 2023-05-04, accepted in 2023-08-08,  发布年份 2023

来源: Frontiers

【 摘 要 】

Enteroviruses are among the most common causes of acute viral illness worldwide, and in neonates, the clinical course of these infections is heterogeneous. Severe complications, such as myocarditis, are associated with high mortality rates. In this case report, we present the clinical course of premature twins born at 35 weeks of gestational age, suffering from a severe neonatal enterovirus infection with cardiac involvement, which proved fatal in one of the twins. This course led to prompt identification in the other twin and facilitated timely transfer to a neonatal intensive care unit with neonatal hemodynamic expertise, and facilitated the timely transfer to a neonatal intensive care nit with hemodynamic expertise and immediate availability of AZCMO would it have been indicated. Early supportive therapy in the other twin contributed to a positive outcome. Therefore, we emphasize the importance of early recognition in averting adverse consequences. As a recommendation, we propose routine screening of enterovirus in viral panels for febrile newborns.

【 授权许可】

Unknown   
© 2023 Storm, De Herdt, Couderé, Verweij, VIRO-TypeNed, Torn, Hundscheid and van Wering.