Can flaxseed supplementation affect circulating adipokines in adults? An updated systematic review and meta-analysis of randomized controlled trials

Frontiers in Nutrition

Nutrition

Kiana Karimi¹  Shaghayegh Abbasi²  Amir Hossein Faghfouri³  Hannane Jozi⁴  Vali Musazadeh⁵  Amir Hossein Moridpour⁵ 

[1] Department of Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran;Department of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran;Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran;Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran;School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran;

关键词: flaxseed;    adiponectin;    leptin;    meta-analysis;    systematic review;   

DOI  :  10.3389/fnut.2023.1179089

 received in 2023-03-03, accepted in 2023-08-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionThe findings of randomized controlled trials (RCTs) regarding the effect of flaxseed on adipokine concentrations are conflicting. Therefore, the present meta-analysis was conducted to provide definite and conclusive results.MethodsSystematically, Scopus, Embase, PubMed, Web of Science databases, and Google Scholar were searched for relevant literature published up to December 2022. Based on random-effect models, standard mean differences (SMDs) were calculated for net changes in adipokine concentrations.ResultsOverall, 13 RCTs (15 arms) were eligible to be included. The results indicated that leptin was significantly reduced after the intervention with flaxseed supplement (SMD = −0.69, 95% CI: −1.37, −0.01; p = 0.048; I2 = 92.0%, p < 0.001). In addition, flaxseed supplements had no considerable effect on plasma adiponectin (SMD = 0.52, 95% CI: −0.20, 1.25, p = 0.159; I2 = 92.0%, p < 0.001).DiscussionFlaxseed significantly improves leptin but does not affect adiponectin concentrations. Additional future well-designed trials are required to further assess the potential benefits of flaxseed on adipokines in humans.

【 授权许可】

Unknown   
Copyright © 2023 Abbasi, Karimi, Hossein Moridpour, Musazadeh, Faghfouri and Jozi.