Decoding the role of gut microbiota in Alzheimer’s pathogenesis and envisioning future therapeutic avenues

Frontiers in Neuroscience

Neuroscience

Hong Zhang¹  Ning Zhang²  Wenhui Cai²  Bin Liu²  Xiaohong Dong²  Junyi Liang²  Yueyang Wang² 

[1] Heilongjiang Jiamusi Central Hospital, Jiamusi, Heilongjiang, China;Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, China;

关键词: Alzheimer’s disease;    gut microbiota;    gut-brain axis mechanism;    memory;    inflammation;    traditional Chinese medicine;    treatment research advancements;   

DOI  :  10.3389/fnins.2023.1242254

 received in 2023-06-18, accepted in 2023-09-04,  发布年份 2023

来源: Frontiers

【 摘 要 】

Alzheimer’s disease (AD) emerges as a perturbing neurodegenerative malady, with a profound comprehension of its underlying pathogenic mechanisms continuing to evade our intellectual grasp. Within the intricate tapestry of human health and affliction, the enteric microbial consortium, ensconced within the milieu of the human gastrointestinal tract, assumes a role of cardinal significance. Recent epochs have borne witness to investigations that posit marked divergences in the composition of the gut microbiota between individuals grappling with AD and those favored by robust health. The composite vicissitudes in the configuration of the enteric microbial assembly are posited to choreograph a participatory role in the inception and progression of AD, facilitated by the intricate conduit acknowledged as the gut-brain axis. Notwithstanding, the precise nature of this interlaced relationship remains enshrouded within the recesses of obscurity, poised for an exhaustive revelation. This review embarks upon the endeavor to focalize meticulously upon the mechanistic sway exerted by the enteric microbiota upon AD, plunging profoundly into the execution of interventions that govern the milieu of enteric microorganisms. In doing so, it bestows relevance upon the therapeutic stratagems that form the bedrock of AD’s management, all whilst casting a prospective gaze into the horizon of medical advancements.

【 授权许可】

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Copyright © 2023 Liang, Liu, Dong, Wang, Cai, Zhang and Zhang.