Urinary exosomes: a promising biomarker of drug-induced nephrotoxicity

Frontiers in Medicine

Medicine

Zunzhen Zhou¹  Yongjing Wang¹  Xiaodan Xu¹  Dailiang Zhang¹  Yuan Jiang¹  Chongzhi Liu¹  Limei Wang²  Yi Yuan³ 

[1] Clinical Medical College, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China;Clinical Medical College, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China;Department of Rehabilitation Medicine, The Third Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China;Orthopedic Department, Dazhou Integrated TCM and Western Medicine Hospital, Dazhou Second People’s Hospital, Dazhou, China;

关键词: drug-induced nephrotoxicity;    acute kidney injury;    biomarkers;    urinary exosomes;    kidney disease;   

DOI  :  10.3389/fmed.2023.1251839

 received in 2023-07-02, accepted in 2023-09-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

Drug-induced nephrotoxicity (DIN) is a big concern for clinical medication, but the clinical use of certain nephrotoxic drugs is still inevitable. Current testing methods make it hard to detect early renal injury accurately. In addition to understanding the pathogenesis and risk factors of drug-induced nephrotoxicity, it is crucial to identify specific renal injury biomarkers for early detection of DIN. Urine is an ideal sample source for biomarkers related to kidney disease, and urinary exosomes have great potential as biomarkers for predicting DIN, which has attracted the attention of many scholars. In the present paper, we will first introduce the mechanism of DIN and the biogenesis of urinary exosomes. Finally, we will discuss the changes in urinary exosomes in DIN and compare them with other predictive indicators to enrich and boost the development of biomarkers of DIN.

【 授权许可】

Unknown   
Copyright © 2023 Zhou, Zhang, Wang, Liu, Wang, Yuan, Xu and Jiang.