Primary mediastinal seminoma presenting with paraneoplastic anti-Hu encephalitis: a case report and literature review

Frontiers in Oncology

Oncology

Chelsey M. Williams¹  Jordan D. Miller²  Adam B. Coleman³  Zin W. Myint⁴  Derek B. Allison⁵  Roshmita Bardhan⁶ 

[1] Department of Internal Medicine, University of Kentucky, Lexington, KY, United States;Division of Thoracic Surgery, University of Kentucky, Lexington, KY, United States;Liberty University College of Osteopathic Medicine, Lynchburg, VA, United States;Markey Cancer Center, University of Kentucky, Lexington, KY, United States;Department of Internal Medicine, Division of Medical Oncology, University of Kentucky, Lexington, KY, United States;Markey Cancer Center, University of Kentucky, Lexington, KY, United States;Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY, United States;University of Pikeville- Kentucky College of Osteopathic Medicine, Pikeville, KY, United States;

关键词: primary mediastinal seminoma;    anti-Hu;    paraneoplastic encephalitis;    ANNA-1;    bilateral hearing loss;    rhombencephalitis;   

DOI  :  10.3389/fonc.2023.1156566

 received in 2023-07-10, accepted in 2023-08-29,  发布年份 2023

来源: Frontiers

【 摘 要 】

Primary mediastinal seminomas are exceedingly rare tumors, often localized to the anterior mediastinum. They may present with numerous complications, including superior vena cava syndrome, chylothorax, and pericardial effusions. Less commonly, they may present with paraneoplastic encephalitis. In this report we describe a case of a 19-year-old male with no significant past medical history who presented with bilateral hearing loss, progressive neuropathy, and ataxia. Subsequently the patient was found to have mediastinal mass with a high-titer anti-Hu antibody. To our knowledge, only one other case of mediastinal seminoma presenting with anti-Hu antibodies has been described in the literature. In this report, we describe a rare case of mediastinal seminoma, describe treatment options, and discuss additional known cases presenting with paraneoplastic encephalitis.

【 授权许可】

Unknown   
Copyright © 2023 Williams, Allison, Coleman, Bardhan, Miller and Myint