Therapeutic potential of bixin on inflammation: a mini review

Frontiers in Nutrition

Nutrition

Xin-Fang Leong¹  Saminathan Shadisvaaran¹  Kok-Yong Chin²  Shahida Mohd-Said³ 

[1] Department of Craniofacial Diagnostics and Biosciences, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia;Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Malaysia;Department of Restorative Dentistry, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia;

关键词: annatto;    Bixa orellana;    bixin;    inflammation;    safety;   

DOI  :  10.3389/fnut.2023.1209248

 received in 2023-04-21, accepted in 2023-08-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

Chronic inflammation is the underlying mechanism for many diseases. Thus, inflammatory signaling pathways are valuable targets for new treatment modalities. Natural products have gained interest as a potential source of bioactive compounds which provide health benefits in combating inflammatory-related diseases. Recent reports have linked the medicinal values of Bixa orellana L. with its anti-inflammatory activities. Therefore, this review aims to examine the therapeutic potential of bixin, a major bioactive constituent found in the seeds of B. orellana, on inflammatory-related diseases based on existing in vitro and in vivo evidence. Additionally, the anti-inflammatory mechanism of bixin via signaling pathways is explored and possible toxic effects are addressed. The findings suggest that bixin may ameliorate inflammation via inhibition of toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-κB), phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) and thioredoxin-interacting protein/NOD-like receptor protein 3 (TXNIP/NLRP3) inflammasome mechanisms. More well-planned clinical studies should be performed to verify its effectiveness and safety profile.

【 授权许可】

Unknown   
Copyright © 2023 Shadisvaaran, Chin, Mohd-Said and Leong.