Quantitative sensory testing in a magnetic resonance environment: considerations for thermal sensitivity and patient safety

Frontiers in Pain Research

Pain Research

Gabriela Comptdaer¹  Edina Szabo¹  Ayeong (Jenny) Kim¹  Christine B. Sieberg²  Claire E. Lunde³  Scott A. Holmes⁴  David Zurakowski⁵ 

[1] Department of Anesthesiology, Critical Care, and Pain Medicine, Pain and Affective Neuroscience Center, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United States;Biobehavioral Pain Innovations Lab, Department of Psychiatry and Behavioral Sciences, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United States;Department of Anesthesiology, Critical Care, and Pain Medicine, Pain and Affective Neuroscience Center, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United States;Biobehavioral Pain Innovations Lab, Department of Psychiatry and Behavioral Sciences, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United States;Department of Psychiatry, Harvard Medical School, Boston, MA, United States;Department of Anesthesiology, Critical Care, and Pain Medicine, Pain and Affective Neuroscience Center, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United States;Biobehavioral Pain Innovations Lab, Department of Psychiatry and Behavioral Sciences, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United States;Nuffield Department of Women’s & Reproductive Health, Oxford University, Oxford, United Kingdom;Department of Anesthesiology, Critical Care, and Pain Medicine, Pain and Affective Neuroscience Center, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United States;Pediatric Pain Pathway Lab, Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United States;Departments of Anesthesiology and Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United States;

关键词: magnetic resonance imaging;    thermal sensitivity;    MR safety;    quantitative sensory testing;    pain;   

DOI  :  10.3389/fpain.2023.1223239

 received in 2023-05-15, accepted in 2023-08-21,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionQuantitative sensory testing (QST) is often used to understand the perceptual basis of acute and chronic conditions, including pain. As the need grows for developing a mechanistic understanding of neurological pathways underlying perception in the basic and clinical sciences, there is a greater need to adapt techniques such as QST to the magnetic resonance (MR) environment. No studies have yet evaluated the impact of the MR environment on the perception of thermal stimuli. This study aimed to evaluate the differences in temperature sensitivity outside an MR environment and during an MRI scanning session. We hypothesized that there would be a difference in how participants reported their pain sensitivity between the two environments.MethodsHealthy participants underwent thermal QST outside the MR scanning environment, where they were asked to rate the temperature of a noxious stimulus at which they perceived their pain to be 7/10, using a Likert scale ranging from 0 to 10. Participants repeated this procedure inside a 3.0 T MRI approximately 30 min later. We repeated our investigation in a clinical cohort of participants with a chronic pain condition.ResultsThere were statistically significant changes of 1.1°C in thermal sensitivity between environments. This increase in pain threshold was found in healthy participants and replicated in the clinical cohort.DiscussionFindings can be applied toward improving MR safety, the resolution of brain pathways underlying pain mechanisms, and to more broadly comment on the impact of the MR environment on investigations that integrate perception-influenced processes.

【 授权许可】

Unknown   
© 2023 Kim, Szabo, Lunde, Comptdaer, Zurakowski, Sieberg and Holmes.