Major depression associated with a levonorgestrel-releasing intrauterine system mimicking frontotemporal dementia: a case report

Frontiers in Psychiatry

Psychiatry

Valeria Valencia-Cifuentes¹  Juan Carlos Rivas²  Carlos A. Cañas³ 

[1] Department of Neurology, Fundación Valle del Lili, Cali, Colombia;Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia;Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia;Department of Psychiatry, Fundación Valle del Lili, Cali, Colombia;Department of Psychiatry, Universidad del Valle, Cali, Colombia;Hospital Departamental Psiquiátrico, Universitario del Valle, Cali, Colombia;Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia;Universidad ICESI, CIRAT: Centro de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional, Cali, Colombia;Department of Rheumatology, Fundación Valle del Lili, Cali, Colombia;

关键词: anxiety;    depressive cognitive disorder;    contraception;    hormonal contraceptive;    progestin-only contraceptive;    adverse event;   

DOI  :  10.3389/fpsyt.2023.1266419

 received in 2023-07-24, accepted in 2023-08-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

This case illustrates the adverse cognitive and affective effects associated with the use of an intrauterine hormonal contraceptive, which could be confused with symptoms of early onset dementia. We present a case of a 42-year-old woman diagnosed with seronegative spondyloarthropathy who subsequently developed anxiety and depressive symptoms after the implantation of a Levonorgestrel-Releasing Intrauterine System (LNG-IUS). Three years later, she began to experience memory and attentional failures, refractory pain, and severe depression. The progression of psychiatric symptoms led to a diagnosis of bipolar affective disorder and treatment with antidepressants and anxiolytics. Due to cognitive and psychiatric symptoms, autoimmune encephalitis was considered, but no improvement was shown with treatment. Early onset dementia was suspected, and a brain PET scan revealed frontal lobe hypometabolism. An adverse effect of LNG-IUS was considered; after its removal, mood and cognitive function improvements were observed. This case report emphasizes the importance of considering organic causes of unexplained psychiatric manifestations and highlights the potential impact of hormonal interventions on mental health.

【 授权许可】

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Copyright © 2023 Valencia-Cifuentes, Cañas and Rivas.