Pemphigus vulgaris as an immune-related adverse event in recurrent metastatic esophageal squamous cell carcinoma treated with ipilimumab plus nivolumab: a case report and literature review

Frontiers in Immunology

Immunology

Aika Shionoya¹  Hisashi Uhara¹  Naotaka Hayasaka²  Kohichi Takada²  Hajime Nakamura²  Tomohiro Kubo²  Yohei Arihara²  Makoto Usami³  Shintaro Sugita⁴ 

[1] Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan;Department of Medical Oncology, Sapporo Medical University School of Medicine, Sapporo, Japan;Department of Medical Oncology, Sapporo Medical University School of Medicine, Sapporo, Japan;Department of Medical Oncology, Steel Memorial Muroran Hospital, Muroran, Japan;Department of Surgical Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan;

关键词: esophageal squamous cell carcinoma;    immune-related adverse events;    ipilimumab;    nivolumab;    pemphigus vulgaris;   

DOI  :  10.3389/fimmu.2023.1259071

 received in 2023-07-15, accepted in 2023-08-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

Ipilimumab plus nivolumab therapy is approved for patients with unresectable advanced esophageal squamous cell carcinoma (ESCC). Although a combination of immune checkpoint inhibitors (ICIs), compared to conventional chemotherapy, can improve overall survival in patients with advanced ESCC, this increases the incidence of immune-related adverse events (irAEs). Here, we describe an ESCC case that developed pemphigus vulgaris (PV), an extremely rare cutaneous irAE, during ipilimumab plus nivolumab treatment. The patient achieved a partial response to treatment. The PV was successfully managed after the cessation of ipilimumab and the use of a topical steroid. We should thus re-treat ESCC with nivolumab monotherapy. In the era of ICIs as standard cancer therapeutics, diagnostic criteria for blistering diseases need to be established to properly manage patients with cutaneous irAEs.

【 授权许可】

Unknown   
Copyright © 2023 Nakamura, Shionoya, Arihara, Hayasaka, Kubo, Usami, Sugita, Uhara and Takada