GABAA receptor availability relates to emotion-induced BOLD responses in the medial prefrontal cortex: simultaneous fMRI/PET with [11C]flumazenil

Frontiers in Neuroscience

Neuroscience

Felix M. Mottaghy¹  Jürgen Scheins²  Jörg Mauler²  Christoph Lerche²  Hans Herzog²  Frank Boers²  Karl-Josef Langen³  Alexander Heinzel⁴  N. Jon Shah⁵  Bernd Neumaier⁶  Georg Northoff⁷ 

[1] Department of Nuclear Medicine, Medical Faculty RWTH Aachen, Aachen, Germany;Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, Netherlands;Institute of Neuroscience and Medicine – 4, Forschungszentrum Jülich, Jülich, Germany;Institute of Neuroscience and Medicine – 4, Forschungszentrum Jülich, Jülich, Germany;Department of Nuclear Medicine, Medical Faculty RWTH Aachen, Aachen, Germany;Institute of Neuroscience and Medicine – 4, Forschungszentrum Jülich, Jülich, Germany;Department of Nuclear Medicine, Medical Faculty RWTH Aachen, Aachen, Germany;Department of Nuclear medicine, University Hospital Halle, Halle (Saale), Germany;Institute of Neuroscience and Medicine – 4, Forschungszentrum Jülich, Jülich, Germany;Institute of Neuroscience and Medicine – 11, Forschungszentrum Jülich, Jülich, Germany;JARA – BRAIN – Translational Medicine, Aachen, Germany;Department of Neurology, RWTH Aachen University, Aachen, Germany;Institute of Neuroscience and Medicine – 5, Forschungszentrum Jülich, Jülich, Germany;Mind, Brain Imaging and Neuroethics Research Unit, Institute of Mental Health, Royal Ottawa Mental Health Centre and University of Ottawa, Ottawa, ON, Canada;

关键词: simultaneous fMRI/PET;    GABA receptor;    emotion;    [C]flumazenil;    BOLD signal;    binding potential;   

DOI  :  10.3389/fnins.2023.1027697

 received in 2022-08-25, accepted in 2023-08-16,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionThe fMRI BOLD response to emotional stimuli highlighting the role of the medial prefrontal cortex (MPFC) has been thoroughly investigated. Recently, the relationship between emotion processing and GABA levels has been studied using MPFC proton magnetic resonance spectroscopy (1H-MRS). However, the role of GABAA receptors in the MPFC during emotion processing remains unexplored.MethodsUsing [11C]flumazenil PET, we investigated the relationship between the binding potential of GABAA receptors and emotion processing as measured using simultaneous fMRI BOLD. We hypothesized a correlation between the percent signal change in the BOLD signal and the binding potential of GABAA receptors in the MPFC. In a combined simultaneous fMRI and [11C]flumazenil-PET study, we analyzed the data from 15 healthy subjects using visual emotional stimuli. Our task comprised two types of emotional processing: passive viewing and appraisal. Following the administration of a bolus plus infusion protocol, PET and fMRI data were simultaneously acquired in a hybrid 3 T MR-BrainPET.ResultsWe found a differential correlation of BOLD percent signal change with [11C]flumazenil binding potential in the MPFC. Specifically, [11C]flumazenil binding potential in the ventromedial prefrontal cortex (vMPFC) correlated with passive viewing of emotionally valenced pictures. In contrast, the [11C]flumazenil binding potential and the BOLD signal induced by picture appraisal did show a correlation in the paracingulate gyrus.ConclusionOur data deliver first evidence for a relationship between MPFC GABAA receptors and emotion processing in the same region. Moreover, we observed that GABAA receptors appear to play different roles in emotion processing in the vMPFC (passive viewing) and paracingulate gyrus (appraisal).

【 授权许可】

Unknown   
Copyright © 2023 Heinzel, Mauler, Herzog, Boers, Mottaghy, Langen, Scheins, Lerche, Neumaier, Northoff and Shah.