期刊论文详细信息
Frontiers in Aging Neuroscience
Mechanistic insights into the role of herpes simplex virus 1 in Alzheimer’s disease
Aging Neuroscience
Shu Feng1  Charles Brenner1  Yu Zhou2  Yongzhen Liu2  Zhenfeng Shu2  Pinghui Feng3  Zhuxi Cheng4 
[1] Department of Diabetes and Cancer Metabolism, City of Hope National Medical Center, Duarte, CA, United States;Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, United States;Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, United States;Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Los Angeles, CA, United States;Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, United States;International Department, Beijing Bayi School, Beijing, China;
关键词: Alzheimer’s disease;    HSV-1;    genetic risk genes;    innate immunity;    metabolism;   
DOI  :  10.3389/fnagi.2023.1245904
 received in 2023-06-27, accepted in 2023-08-21,  发布年份 2023
来源: Frontiers
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【 摘 要 】

Alzheimer’s Disease (AD) is an aging-associated neurodegenerative disorder, threatening millions of people worldwide. The onset and progression of AD can be accelerated by environmental risk factors, such as bacterial and viral infections. Human herpesviruses are ubiquitous infectious agents that underpin numerous inflammatory disorders including neurodegenerative diseases. Published studies concerning human herpesviruses in AD imply an active role HSV-1 in the pathogenesis of AD. This review will summarize the current understanding of HSV-1 infection in AD and highlight some barriers to advance this emerging field.

【 授权许可】

Unknown   
Copyright © 2023 Feng, Liu, Zhou, Shu, Cheng, Brenner and Feng.

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