Bidirectional crosstalk between the peripheral nervous system and lymphoid tissues/organs

Frontiers in Immunology

Immunology

Angela Boahen¹  Dailun Hu²  Bin Ma³  Philip K. Nicholls³  Murray J. Adams³  Wayne K. Greene³ 

[1] Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Seri-Kembangan, Selangor, Malaysia;Department of Pathogenic Biology, Hebei Medical University, Shijiazhuang, Hebei, China;School of Medical, Molecular and Forensic Sciences, Murdoch University, Murdoch, WA, Australia;

关键词: neuroimmunology;    lymphoid tissues/organs;    peripheral nervous system;    innervation;    neuroimmune cell units;    autonomic nervous system;   

DOI  :  10.3389/fimmu.2023.1254054

 received in 2023-07-06, accepted in 2023-08-25,  发布年份 2023

来源: Frontiers

【 摘 要 】

The central nervous system (CNS) influences the immune system generally by regulating the systemic concentration of humoral substances (e.g., cortisol and epinephrine), whereas the peripheral nervous system (PNS) communicates specifically with the immune system according to local interactions/connections. An imbalance between the components of the PNS might contribute to pathogenesis and the further development of certain diseases. In this review, we have explored the “thread” (hardwiring) of the connections between the immune system (e.g., primary/secondary/tertiary lymphoid tissues/organs) and PNS (e.g., sensory, sympathetic, parasympathetic, and enteric nervous systems (ENS)) in health and disease in vitro and in vivo. Neuroimmune cell units provide an anatomical and physiological basis for bidirectional crosstalk between the PNS and the immune system in peripheral tissues, including lymphoid tissues and organs. These neuroimmune interactions/modulation studies might greatly contribute to a better understanding of the mechanisms through which the PNS possibly affects cellular and humoral-mediated immune responses or vice versa in health and diseases. Physical, chemical, pharmacological, and other manipulations of these neuroimmune interactions should bring about the development of practical therapeutic applications for certain neurological, neuroimmunological, infectious, inflammatory, and immunological disorders/diseases.

【 授权许可】

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Copyright © 2023 Boahen, Hu, Adams, Nicholls, Greene and Ma