Frontiers in Veterinary Science | |
Cross-protection of commercial vaccines against Chilean swine influenza A virus using the guinea pig model as a surrogate | |
Veterinary Science | |
Rafael A. Medina1  Rodrigo Tapia2  Victoria García2  Juan Mena2  Victor Neira2  Marie Culhane3  | |
[1] Department of Pathology and Experimental Medicine, School of Medicine, Emory University, Atlanta, GA, United States;Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States;Departamento de Enfermedades Infecciosas e Inmunología Pediátrica, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile;Medicina Preventiva Animal, Facultad de Ciencias Veterinarias, Universidad de Chile, Santiago, Chile;Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, MN, United States; | |
关键词: influenza; swine; vaccine; cross-protection; guinea pig model; surrogate; | |
DOI : 10.3389/fvets.2023.1245278 | |
received in 2023-06-23, accepted in 2023-08-21, 发布年份 2023 | |
来源: Frontiers | |
【 摘 要 】
Influenza A virus poses a significant threat to public health and the swine industry. Vaccination is the primary measure for controlling the disease, but the effectiveness of vaccines can vary depending on the antigenic match between vaccine strains and circulating strains. In Chile, H1N1pdm09 and other lineages H1N2 and H3N2 have been detected in pigs, which are genetically distinct from the strains included in commercial vaccines. This study aimed to evaluate the cross-protection by commercial vaccines against strains circulating in Chile using the guinea pig model. For this study, four circulating strains [A/swine/Chile/H1A-7/2014(H1N2), A/swine/Chile/H1B-2/2014(H1N2), A/swine/Chile/H1P-12/2015(H1N1), and A/swine/Chile/H3-2/2015(H3N2)] were selected. Guinea pigs were divided into vaccinated and control groups. The vaccinated animals received either a multivalent antigenically heterologous or monovalent homologous vaccine, while the control animals remained unvaccinated. Following vaccination, all animals were intranasally challenged, and nasal wash samples were collected at different time points post-infection. The results showed that the homologous monovalent vaccine-induced hemagglutinin-specific antibodies against the Chilean pandemic H1N1pdm09 strain. However, the commercial heterologous multivalent vaccine failed to induce hemagglutinin-specific antibody titers against the H1N2 and H3N2 challenge strains. Furthermore, the homologous monovalent vaccine significantly reduced the duration of viral shedding and viral titers specifically against the Chilean pandemic H1N1pdm09 strain and heterologous multivalent vaccine only partial. These findings highlight the importance of regularly updating vaccine strains to match the circulating field strains for effective control of swine influenza. Further research is needed to develop vaccines that confer broader protection against diverse strains of swine influenza A virus.
【 授权许可】
Unknown
Copyright © 2023 Tapia, Mena, García, Culhane, Medina and Neira.
【 预 览 】
Files | Size | Format | View |
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RO202310122926581ZK.pdf | 650KB | download |