The relationship between frequent premature ventricular complexes and epicardial adipose tissue volume

Frontiers in Endocrinology

Endocrinology

Yihong Sun¹  Siqi Jiao¹  Zhe Wang²  Jiawei Chen²  Liping Sun²  Yingwei Chen²  Lichen Ren³  Hehe Guo³ 

[1] Department of Cardiology, Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China;Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;

关键词: premature ventricular complexes;    epicardial adipose tissue;    computed tomography;    burden levels;    propensity score matching;   

DOI  :  10.3389/fendo.2023.1219890

 received in 2023-05-09, accepted in 2023-08-25,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundEpicardial adipose tissue (EAT) is related to atrial fibrillation. The association between EAT volume and premature ventricular complexes (PVCs) remains unclear. Our study aimed to investigate the effect of EAT volume on the risk of frequent PVCs and burden levels of PVCs.MethodsThis observational study retrospectively recruited consecutive patients who had consultation between 2019 and 2021 at the First Affiliated Hospital of Zhengzhou University. Frequent PVC patients (n = 402) and control patients (n = 402) undergoing non-contrast computed tomography (CT) were enrolled. We selected evaluation criteria for the conduct of a 1:1 propensity score matching (PSM) analysis. Multivariable logistic analysis was used to investigate factors related to frequent PVCs. Furthermore, the determinants of EAT volume and the burden levels of PVCs were evaluated.ResultsPatients with PVCs had a significantly larger EAT volume than control patients. EAT volume was significantly larger in male PVC patients with BMI ≥24 kg/m2, diabetes mellitus, and E/A ratio <1. EAT volume was independently associated with PVCs. Moreover, the larger EAT volume was an independent predictor for the high burden level of PVCs. We revealed that the risk of high PVC burden level was increased with the rising of EAT volume by restricted cubic splines.ConclusionsEAT volume was larger in frequent PVC patients than in control patients, regardless of other confounding factors. A large EAT volume was independently associated with high burden levels of PVCs. EAT volume may be a new mechanism to explain the pathogenesis of PVCs.

【 授权许可】

Unknown   
Copyright © 2023 Wang, Jiao, Chen, Guo, Ren, Sun, Sun and Chen