The age of computational cardiology and future of long-term ablation target prediction for ventricular tachycardia

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Syed Yusuf Ali¹  Ashish Goel²  Yashendra Sethi³  Ranjit Sah⁴  Joshuan J. Barboza⁵  Prakasini Satapathy⁶  Mohammed K. Suhail⁷  Neil Patel⁸  Nirja Kaka⁸  Arsalan Moinuddin⁹ 

[1] Department of Biomedical Engineering, Johns Hopkins University, Balimore, MD, United States;Department of Medicine, Government Doon Medical College, Dehradun, India;Department of Medicine, Government Doon Medical College, Dehradun, India;PearResearch, Dehradun, India;Department of Microbiology, Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal;Department of Microbiology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, India;Department of Public Health Dentistry, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, India;Escuela de Medicina, Universidad César Vallejo, Trujillo, Peru;Global Center for Evidence Synthesis, Chandigarh, India;Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India;Moray House, University of Edinburgh, Edinburgh, United Kingdom;PearResearch, Dehradun, India;Department of Medicine, GMERS Medical College, Himmatnagar, India;School of Sport and Exercise, University of Gloucestershire, Gloucester, United Kingdom;

关键词: ventricular tachycardia;    catheter ablation;    computational cardiology;    metabolic sink theory;    precision medicine;   

DOI  :  10.3389/fcvm.2023.1233991

 received in 2023-06-03, accepted in 2023-08-30,  发布年份 2023

来源: Frontiers

【 摘 要 】

Ventricular arrhythmias, particularly ventricular tachycardia, are ubiquitously linked to 300,000 deaths annually. However, the current interventional procedure—the cardiac ablation—predict only short-term responses to treatment as the heart constantly remodels itself post-arrhythmia. To assist in the design of computational methods which focuses on long-term arrhythmia prediction, this review postulates three interdependent prospectives. The main objective is to propose computational methods for predicting long-term heart response to interventions in ventricular tachycardia Following a general discussion on the importance of devising simulations predicting long-term heart response to interventions, each of the following is discussed: (i) application of “metabolic sink theory” to elucidate the “re-entry” mechanism of ventricular tachycardia; (ii) application of “growth laws” to explain “mechanical load” translation in ventricular tachycardia; (iii) derivation of partial differential equations (PDE) to establish a pipeline to predict long-term clinical outcomes in ventricular tachycardia.

【 授权许可】

Unknown   
© 2023 Moinuddin, Ali, Goel, Sethi, Patel, Kaka, Satapathy, Sah, Barboza and Suhail.