Potential for transmission of naturally mutated H10N1 avian influenza virus to mammalian hosts and causing severe pulmonary disease

Frontiers in Microbiology

Microbiology

Jaehyun Hwang¹  Hyung-Jun Kwon¹  Eul Hae Ga¹  Woonsung Na¹  Daesub Song²  Hye Kwon Kim³  Hae-Jin Cho⁴  Dae Gwin Jeong⁵  Tran Bac Le⁵  Jung-Ah Kang⁵  Sun-Woo Yoon⁶  Mark Zanin⁷  Sook-San Wong⁷ 

[1] College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea;College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea;Department of Microbiology, College of Natural Sciences, Chungbuk National University, Cheongju, Republic of Korea;Korea Institute of Environment Ecology, Daejeon, Republic of Korea;Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea;Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea;Department of Vaccine Biotechnology, College of Life Sciences and Health Welfare, Andong National University, Andong, Republic of Korea;School of Public Health, The University of Hong Kong, Hong Kong, Hong Kong SAR, China;

关键词: avian influenza;    H10N1;    wild bird;    zoonosis;    transmission;    ferret model;   

DOI  :  10.3389/fmicb.2023.1256090

 received in 2023-07-10, accepted in 2023-08-21,  发布年份 2023

来源: Frontiers

【 摘 要 】

Subtype H10 avian influenza viruses (AIV) are distributed worldwide in wild aquatic birds, and can infect humans and several other mammalian species. In the present study, we investigated the naturally mutated PB2 gene in A/aquatic bird/South Korea/SW1/2018 (A/SW1/18, H10N1), isolated from wild birds during the 2018–2019 winter season. This virus was originally found in South Korea, and is similar to isolates from mainland China and Mongolia. It had low pathogenicity, lacked a multi-basic cleavage site, and showed a binding preference for α2,3-linked sialic acids. However, it can infect mice, causing severe disease and lung pathology. SW1 was also transmitted by direct contact in ferrets, and replicated in the respiratory tract tissue, with no evidence of extrapulmonary spread. The pathogenicity and transmissibility of SW1 in mouse and ferret models were similar to those of the pandemic strain A/California/04/2009 (A/CA/04, H1N1). These factors suggest that subtype H10 AIVs have zoonotic potential and may transmit from human to human, thereby posing a potential threat to public health. Therefore, the study highlights the urgent need for closer monitoring of subtype H10 AIVs through continued surveillance of wild aquatic birds.

【 授权许可】

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Copyright © 2023 Zanin, Le, Na, Kang, Kwon, Hwang, Ga, Wong, Cho, Song, Kim, Jeong and Yoon.