Protective effects of curcumin against osteoporosis and its molecular mechanisms: a recent review in preclinical trials

Frontiers in Pharmacology

Pharmacology

Xin’an Zhang¹  Shenglei Yang¹  Yue Huang¹  Leonid Kapilevich²  Yuying Sun³ 

[1] College of Exercise and Health, Shenyang Sport University, Shenyang, China;Faculty of Physical Education, Nаtionаl Reseаrch Tomsk Stаte University, Tomsk, Russiа;School of Stomatology, Binzhou Medical College, Yantai, China;

关键词: osteoporosis;    curcumin;    osteoblast;    osteoclast;    mechanism;   

DOI  :  10.3389/fphar.2023.1249418

 received in 2023-06-28, accepted in 2023-09-04,  发布年份 2023

来源: Frontiers

【 摘 要 】

Osteoporosis (OP) is one of the most common metabolic skeletal disorders and is commonly seen in the elderly population and postmenopausal women. It is mainly associated with progressive loss of bone mineral density, persistent deterioration of bone microarchitecture, and increased fracture risk. To date, drug therapy is the primary method used to prevent and treat osteoporosis. However, long-term drug therapy inevitably leads to drug resistance and specific side effects. Therefore, researchers are constantly searching for new monomer compounds from natural plants. As a candidate for the treatment of osteoporosis, curcumin (CUR) is a natural phenolic compound with various pharmacological and biological activities, including antioxidant, anti-apoptotic, and anti-inflammatory. This compound has gained research attention for maintaining bone health in various osteoporosis models. We reviewed preclinical and clinical studies of curcumin in preventing and alleviating osteoporosis. These results suggest that if subjected to rigorous pharmacological and clinical trials, naturally-derived curcumin could be used as a complementary and alternative medicine for the treatment of osteoporosis by targeting osteoporosis-related mechanistic pathways. This review summarizes the mechanisms of action and potential therapeutic applications of curcumin in the prevention and mitigation of osteoporosis and provides reference for further research and development of curcumin.

【 授权许可】

Unknown   
Copyright © 2023 Yang, Sun, Kapilevich, Zhang and Huang.