The correlation of urinary strontium with the risk of chronic kidney disease among the general United States population

Frontiers in Public Health

Public Health

Ming Pu¹  Jiayue Li¹  Fenglian Zhang²  Dan Liao²  Na Hu²  Yuanmei Li²  Xinchun Li³ 

[1] Chengdu Medical College, Chengdu, China;Department of Nephrology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China;North Sichuan Medical College, Nanchong, China;

关键词: chronic kidney disease;    heavy metal;    kidney function;    NHANES;    urinary strontium;   

DOI  :  10.3389/fpubh.2023.1251232

 received in 2023-07-01, accepted in 2023-08-23,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundThis study sought to illustrate whether urinary strontium levels were related to developing chronic kidney disease (CKD) in the United States population.MethodsA total of 5,005 subjects were identified from the National Health and Nutrition Examination Survey 2011–2016. Survey-weighted logistic regression analysis, multivariate linear regression analysis, restricted cubic spline (RCS) plots curve and stratified analyses were undertaken to explicate the correlation between urinary strontium and CKD.ResultsWith the increase of urinary strontium, the incidence rate of CKD and urinary albumin to creatinine ratio (UACR) levels gradually decreased, and estimated glomerular filtration rate (eGFR) levels gradually increased. After controlling all confounders, only urinary strontium in the fourth quartile was correlated to a lower CKD prevalence (OR: 0.59; 95% CI, 0.44–0.79) compared to the lowest quartile. Multivariate linear regression analysis showed that urinary strontium was positively correlated with eGFR but negatively with UACR. RCS curve suggested a nonlinear relationship between urinary strontium and CKD (P for non-linearity <0.001). Stratified analyses indicated no significant difference in the correlation between urinary strontium and CKD among different subgroups.ConclusionUrinary strontium was strongly correlated with a low risk of CKD, and this association was non-linear among the US population.

【 授权许可】

Unknown   
Copyright © 2023 Zhang, Hu, Li, Pu, Li, Li and Liao.