Neuropsychiatric disturbance detecting polycythemia vera myelofibrosis: a case report and literature review

Frontiers in Neurology

Neurology

Li Li¹  Min Zhou¹  Wei-Nv Fan¹  Yun-Qin Wu¹  Da Li² 

[1] Department of Neurology, Ningbo No 2 Hospital, Ningbo, Zhejiang, China;null;

关键词: post-polycythemia vera myelofibrosis (post-PV MF);    neuropsychiatric symptoms (NPS);    chorea;    microcirculation disorder;    Janus kinase 2 (JAK2);   

DOI  :  10.3389/fneur.2023.1253468

 received in 2023-07-07, accepted in 2023-09-05,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundNeuropsychiatric disturbances and chorea are less recognized consequences of polycythemia vera (PV), and their role in post-PV myelofibrosis (MF) has not been reported. Clinical features that predict post-PV MF lack specificity.Case presentationWe describe an elderly patient with PV who developed acute-onset reversible neuropsychiatric disturbances accompanied by generalized chorea and was finally diagnosed with post-PV MF after a bone marrow examination. We also reviewed four cases of late PV associated with neuropsychiatric symptoms since 1966 and analyzed their clinical characteristics and therapeutic effects.ConclusionOur case indicates that Janus kinase 2 (JAK2)-related PV is a treatable cause of late-onset chorea and that chorea may herald the deterioration of hematological parameters. Our case provides a clinically specific representation of post-PV MF. Patients with a long course of PV are recommended to undergo bone marrow re-examinations when they present with neuropsychiatric symptoms to achieve an early diagnosis of post-PV MF.

【 授权许可】

Unknown   
Copyright © 2023 Li, Zhou, Wu, Fan and Li.