Association between precocious puberty and obesity risk in children: a systematic review and meta-analysis

Frontiers in Pediatrics

Pediatrics

Yongji Wang¹  Yibu Kong²  Na Wang²  Yongfu Song²  Xiaofei Xie² 

[1] Correspondence:;Department of Pediatrics, Hospital Affiliated to Changchun Traditional Chinese Medicine University, Changchun, China;

关键词: precocious puberty;    general obesity;    central obesity;    overweight;    meta-analysis;   

DOI  :  10.3389/fped.2023.1226933

 received in 2023-05-22, accepted in 2023-07-31,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectivesThe aim of this study was to evaluate the potential association between early onset puberty and the risk of different forms of obesity in children.MethodsThe databases PubMed, EMBASE, Web of Science and Cochrane Library were systematically searched for relevant studies. The odds ratio (OR) and 95% confidence interval (CI) of obesity in precocious puberty were calculated using Stata software 14.0. A fixed-effects model was used if P > 0.1 and I2 ≤ 50%. Otherwise, a random-effects model was used. Publication bias was assessed using funnel plots and Egger's test.ResultThe pooling analysis showed that precocious puberty in girls was associated with a higher risk of obesity (OR = 1.98; 95% CI: 1.76–2.24; I2 = 0.00%, P < 0.001). Girls with a history of precocious puberty were found to have an increased risk of general obesity (OR = 2.03; 95% CI: 1.62–2.55; I2 = 22.2%, P < 0.001), central obesity (OR = 1.96; 95% CI: 1.70–2.26; I2 = 0.00%, P < 0.001), and overweight (OR = 2.03; 95% CI: 1.68–2.46; I2 = 5.1%, P < 0.001). The pooled analysis showed that precocious puberty in boys was not associated with an increased risk of obesity (OR = 1.14; 95% CI: 0.86–1.51; I2 = 50.6%, P = 0.369). In boys, the occurrence of precocious puberty was not associated with an elevated risk of general obesity (OR = 0.96; 95% CI: 0.40–2.27; I2 = 79.6%, P = 0.922), central obesity (OR = 1.17; 95% CI: 0.96–1.43; I2 = 0.00%, P = 0.125), or overweight (OR = 1.03; 95% CI: 0.56–1.88; I2 = 74.4%, P = 0.930).ConclusionThis meta-analysis suggests that the onset of puberty at an early age in girls is associated with an increased risk of obesity, however precocious puberty in boy was not associated with an increased risk of obesity. These findings highlight that precocious puberty should be considered an independent risk factor for obesity in girls.Systematic Review RegistrationCRD42023404479.

【 授权许可】

Unknown   
© 2023 Song, Kong, Xie, Wang and Wang.