Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis

Frontiers in Endocrinology

Endocrinology

Ali Al-kassab-Córdova¹  Esteban A. Alarcon-Braga²  Juan C. Cabrera-Guzmán²  Juan R. Ulloque-Badaracco²  Enrique A. Hernandez-Bustamante³  Vicente A. Benites-Zapata⁴  Percy Herrera-Añazco⁵ 

[1] Centro de Excelencia en Investigaciones Económicas y Sociales en Salud, Universidad San Ignacio de Loyola, Lima, Peru;Facultad De Ciencias De La Salud, Universidad Peruana De Ciencias Aplicadas, Lima, Peru;Sociedad Científica De Estudiantes De Medicina De La Universidad Nacional De Trujillo, Trujillo, Peru;Grupo Peruano De Investigación Epidemiológica, Unidad Para La Generación y Síntesis De Evidencias En Salud, Universidad San Ignacio De Loyola, Lima, Peru;Unidad De Investigación Para La Generación y Síntesis De Evidencias En Salud, Vicerrectorado De Investigación, Universidad San Ignacio De Loyola, Lima, Peru;Universidad Privada Del Norte, Trujillo, Peru;Red Peruana De Salud Colectiva, Lima, Peru;

关键词: metabolic syndrome;    folate;    vitamin B12;    homocysteine;    meta-analysis;   

DOI  :  10.3389/fendo.2023.1221259

 received in 2023-05-12, accepted in 2023-08-22,  发布年份 2023

来源: Frontiers

【 摘 要 】

Background & aimsMetabolic syndrome (MetS) is associated with life-threatening conditions. Several studies have reported an association of vitamin B12, folic acid, or homocysteine (Hcy) levels with MetS. This systematic review and meta-analysis assessed the association of vitamin B12, folic acid, and Hcy levels with MetS.MethodsPubMed, Scopus, Embase, Ovid/Medline, and Web of Science were searched up to February 13, 2023. Cross-sectional, case-control, or cohort studies were included. A random-effects model was performed using the DerSimonian and Laird method to estimate the between-study variance. Effect measures were expressed as odds ratios (OR) with their corresponding 95% confidence intervals (95% CI). Between-study heterogeneity was evaluated using Cochran’s Q test and the I2 statistic.ResultsSixty-six articles (n = 87,988 patients) were included. Higher vitamin B12 levels were inversely associated with MetS (OR = 0.87; 95% CI: 0.81–0.93; p < 0.01; I2 = 90%). Higher Hcy levels were associated with MetS (OR = 1.19; 95% CI: 1.14–1.24; p < 0.01; I2 = 90%). Folate levels were not associated with MetS (OR = 0.83; 95% CI: 0.66–1.03; p = 0.09; I2 = 90%).ConclusionHigher vitamin B12 levels were inversely associated with MetS, whereas higher Hcy levels were associated with MetS. Studies assessing the pathways underlying this association are required.

【 授权许可】

Unknown   
Copyright © 2023 Ulloque-Badaracco, Hernandez-Bustamante, Alarcon-Braga, Al-kassab-Córdova, Cabrera-Guzmán, Herrera-Añazco and Benites-Zapata