Effect of the Mediterranean diet supplemented with nicotinamide riboside and pterostilbene and/or coconut oil on anthropometric variables in amyotrophic lateral sclerosis. A pilot study

Frontiers in Nutrition

Nutrition

Mario Zacarés¹  Mari Ángeles Navarro¹  Eraci Drehmer²  María Jesús Vega-Bello³  Mari Luz Moreno³  José Enrique de la Rubia Ortí⁴  Sandra Carrera-Juliá⁵  José M. Estrela⁶ 

[1] Department of Basic and Transversal Sciences, Catholic University of Valencia San Vicente Mártir, Valencia, Spain;Department of Health and Functional Assessment, Catholic University of Valencia San Vicente Mártir, Valencia, Spain;Department of Human Anatomy and Physiology, Catholic University of Valencia San Vicente Mártir, Valencia, Spain;Department of Nursery, Catholic University of Valencia San Vicente Mártir, Valencia, Spain;Department of Nutrition and Dietetics, Catholic University of Valencia San Vicente Mártir, Valencia, Spain;Department of Physiology, University of Valencia, Valencia, Spain;

关键词: amyotrophic lateral sclerosis;    nicotinamide riboside;    pterostilbene;    coconut oil;    nutrition;    anthropometry;   

DOI  :  10.3389/fnut.2023.1232184

 received in 2023-06-05, accepted in 2023-09-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

Amyotrophic Lateral Sclerosis (ALS) is a chronic and progressive neurodegenerative disease that causes the death of motor neurons and alters patients’ body composition. Supplementation with the antioxidants nicotinamide riboside (NR) and pterostilbene (PTER) can combat associated oxidative stress. Additionally, coconut oil is an alternative energy substrate that can address mitochondrial dysfunction. The aim of the present study is to assess the impact of a Mediterranean Diet supplemented with NR and PTER and/or with coconut oil on the anthropometric variables of patients with ALS. A prospective, mixed, randomized, analytical and experimental pilot study in humans was performed through a clinical trial (registered with ClinicalTrials.gov under number NCT03489200) with pre- and post-intervention assessments. The sample was made up of 40 subjects categorized into four study groups (Control, Antioxidants, Coconut oil, and Antioxidants + Coconut oil). Pre- and post-intervention anthropometric assessments were carried out to determine the following data: weight, percentage of fat and muscle mass, skinfolds, body perimeters, Body Mass Index (BMI), Waste-to-Hip Index (WHI) and Waist-Height Ratio (WHR). Compared to the Control group, GAx significantly increased muscle mass percentage and decreased fat mass percentage, triceps, iliac crest, and abdominal skinfolds. GCoco significantly increased muscle mass percentage and decreased fat mass percentage, subscapular skinfolds, and abdominal skinfolds. GAx + coco significantly increased muscle mass percentage and decreased abdominal skinfolds. Therefore, our results suggest that the Mediterranean Diet supplemented with NR and PTER and the Mediterranean Diet supplemented with coconut oil (ketogenic diet) are the two nutritional interventions that have reported the greatest benefits, at anthropometric level.

【 授权许可】

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Copyright © 2023 Carrera-Juliá, Estrela, Zacarés, Navarro, Vega-Bello, de la Rubia Ortí, Moreno and Drehmer.