cGAS–STING pathway in ischemia-reperfusion injury: a potential target to improve transplantation outcomes

Frontiers in Immunology

Immunology

Zijian Chen¹  Zeying Lin¹  Weizhe Huang¹  Yangqi Liu¹ 

[1] Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China;

关键词: allografts;    cGAS-STING;    ischemia-reperfusion injury;    programmed cell death;    transplantation;    inflammation;   

DOI  :  10.3389/fimmu.2023.1231057

 received in 2023-05-30, accepted in 2023-09-04,  发布年份 2023

来源: Frontiers

【 摘 要 】

Transplantation is an important life-saving therapeutic choice for patients with organ or tissue failure once all other treatment options are exhausted. However, most allografts become damaged over an extended period, and post-transplantation survival is limited. Ischemia reperfusion injury (IRI) tends to be associated with a poor prognosis; resultant severe primary graft dysfunction is the main cause of transplant failure. Targeting the cGAS–STING pathway has recently been shown to be an effective approach for improving transplantation outcomes, when activated or inhibited cGAS–STING pathway, IRI can be alleviated by regulating inflammatory response and programmed cell death. Thus, continuing efforts to develop selective agonists and antagonists may bring great hopes to post-transplant patient. In this mini-review, we reviewed the role of the cGAS–STING pathway in transplantation, and summarized the crosstalk between this pathway and inflammatory response and programmed cell death during IRI, aiming to provide novel insights into the development of therapies to improve patient outcome after transplantation.

【 授权许可】

Unknown   
Copyright © 2023 Chen, Liu, Lin and Huang