Diverse roles of lung macrophages in the immune response to influenza A virus

Frontiers in Microbiology

Microbiology

Haoning Li¹  Fanhua Wei¹  Aoxue Wang¹  Yuying Zhang² 

[1] College of Animal Science and Technology, Ningxia University, Yinchuan, China;School of Biological Science and Technology, University of Jinan, Jinan, China;

关键词: influenza virus;    macrophage;    antiviral;    immune response;    inflammation;   

DOI  :  10.3389/fmicb.2023.1260543

 received in 2023-07-18, accepted in 2023-08-16,  发布年份 2023

来源: Frontiers

【 摘 要 】

Influenza viruses are one of the major causes of human respiratory infections and the newly emerging and re-emerging strains of influenza virus are the cause of seasonal epidemics and occasional pandemics, resulting in a huge threat to global public health systems. As one of the early immune cells can rapidly recognize and respond to influenza viruses in the respiratory, lung macrophages play an important role in controlling the severity of influenza disease by limiting viral replication, modulating the local inflammatory response, and initiating subsequent adaptive immune responses. However, influenza virus reproduction in macrophages is both strain- and macrophage type-dependent, and ineffective replication of some viral strains in mouse macrophages has been observed. This review discusses the function of lung macrophages in influenza virus infection in order to better understand the pathogenesis of the influenza virus.

【 授权许可】

Unknown   
Copyright © 2023 Li, Wang, Zhang and Wei.