Imbalance of thalamic metabolites in an experimental model of hypertension: role of bergamot polyphenols

Frontiers in Integrative Neuroscience

Neuroscience

Vincenzo Musolino¹  Micaela Gliozzi²  Annachiara Mollace²  Anna Rita Coppoletta²  Vincenzo Mollace²  Antonio Cardamone²  Cristina Carresi³ 

[1] Pharmaceutical Biology Laboratory, Department of Health Sciences, Interregional Research Center for Food Safety and Health IRC-FSH, University “Magna Græcia” of Catanzaro, Catanzaro, Italy;Pharmacology Laboratory, Department of Health Sciences, Interregional Research Center for Food Safety and Health IRC-FSH, University “Magna Græcia” of Catanzaro, Catanzaro, Italy;Veterinary Pharmacology Laboratory, Department of Health Sciences, Interregional Research Center for Food Safety and Health IRC-FSH, University “Magna Graecia” of Catanzaro, Catanzaro, Italy;

关键词: hypertension;    cerebral metabolites;    thalamus;    polyphenols;    bergamot;   

DOI  :  10.3389/fnint.2023.1271005

 received in 2023-08-01, accepted in 2023-09-01,  发布年份 2023

来源: Frontiers

【 摘 要 】

Cerebral metabolites are associated with different physiological and pathological processes in brain tissue. Among them, the concentrations of N-acetylaspartate (NAA) and choline-containing compounds (Cho) in the thalamic region are recognized and analyzed as important predictive markers of brain impairment. The relationship among hypertension, modulation of brain metabolite levels and cerebral diseases is of recent investigation, leaving many unanswered questions regarding the origin and consequences of the metabolic damage caused in grey and white matter during hypertension. Here we provide evidence for the influence of hypertension on NAA and Cho ratios in hypertensive rat thalamus and how the use of natural occurring compounds ameliorates the balance of thalamic metabolites.

【 授权许可】

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Copyright © 2023 Carresi, Cardamone, Coppoletta, Mollace, Musolino, Gliozzi and Mollace.