Resting-state prefrontal EEG biomarker in correlation with postoperative delirium in elderly patients

Frontiers in Aging Neuroscience

Neuroscience

Bon-Nyeo Koo¹  Jeongmin Kim¹  Ki-young Lee¹  Sujung Park¹  Sang-Jun Shin²  Keung-Nyun Kim³  Yoon Ha⁴  Wonseok Cha⁵  Jungmi Choi⁵ 

[1] Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea;Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea;Department of Biomedical Systems Informatics, Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea;Department of Neurosurgery, Spine and Spinal Cord Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea;Department of Neurosurgery, Spine and Spinal Cord Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea;POSTECH Biotech Center, Pohang University of Science and Technology, Pohang, Republic of Korea;Human Anti-Aging Standards Research Institute, Gyeongsangnam-Do, Republic of Korea;

关键词: electroencephalography;    elderly;    median dominant frequency;    postoperative delirium;    postoperative complications;   

DOI  :  10.3389/fnagi.2023.1224264

 received in 2023-05-17, accepted in 2023-09-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

Postoperative delirium (POD) is associated with adverse outcomes in elderly patients after surgery. Electroencephalography (EEG) can be used to develop a potential biomarker for degenerative cerebral dysfunctions, including mild cognitive impairment and dementia. This study aimed to explore the relationship between preoperative EEG and POD. We included 257 patients aged >70 years who underwent spinal surgery. We measured the median dominant frequency (MDF), which is a resting-state EEG biomarker involving intrinsic alpha oscillations that reflect an idle cortical state, from the prefrontal regions. Additionally, the mini-mental state examination and Montreal cognitive assessment (MoCA) were performed before surgery as well as 5 days after surgery. For long-term cognitive function follow up, the telephone interview for cognitive status™ (TICS) was performed 1 month and 1 year after surgery. Fifty-two (20.2%) patients were diagnosed with POD. A multivariable logistic regression analysis that included age, MoCA score, Charlson comorbidity index score, Mini Nutritional Assessment, and the MDF as variables revealed that the MDF had a significant odds ratio of 0.48 (95% confidence interval 0.27–0.85). Among the patients with POD, the postoperative neurocognitive disorders could last up to 1 year. Low MDF on preoperative EEG was associated with POD in elderly patients undergoing surgery. EEG could be a novel potential tool for identifying patients at a high risk of POD.

【 授权许可】

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Copyright © 2023 Kim, Park, Kim, Ha, Shin, Cha, Lee, Choi and Koo.