Drugs for treating myocardial fibrosis

Frontiers in Pharmacology

Pharmacology

Xiufen Liu¹  Li Ling¹  Zhanhong Ren¹  Zixuan Zhang²  Xin Wang³ 

[1] Hubei Key Laboratory of Diabetes and Angiopathy, Medicine Research Institute, Xianning Medical College, Hubei University of Science and Technology, Xianning, China;Hubei Key Laboratory of Diabetes and Angiopathy, Medicine Research Institute, Xianning Medical College, Hubei University of Science and Technology, Xianning, China;School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, China;School of Mathematics and Statistics, Hubei University of Science and Technology, Xianning, China;

关键词: myocardial fibrosis;    modern medicine;    traditional Chinese medicine;    integrated traditional Chinese and modern medicine;    mechanism;   

DOI  :  10.3389/fphar.2023.1221881

 received in 2023-05-13, accepted in 2023-08-29,  发布年份 2023

来源: Frontiers

【 摘 要 】

Myocardial fibrosis, which is a common pathological manifestation of many cardiovascular diseases, is characterized by excessive proliferation, collagen deposition and abnormal distribution of extracellular matrix fibroblasts. In clinical practice, modern medicines, such as diuretic and β receptor blockers, and traditional Chinese medicines, such as salvia miltiorrhiza and safflower extract, have certain therapeutic effects on myocardial fibrosis. We reviewed some representative modern medicines and traditional Chinese medicines (TCMs) and their related molecular mechanisms for the treatment of myocardial fibrosis. These drugs alleviate myocardial fibrosis by affecting related signaling pathways and inhibiting myocardial fibrosis-related protein synthesis. This review will provide more references and help for the research and treatment of myocardial fibrosis.

【 授权许可】

Unknown   
Copyright © 2023 Ren, Zhang, Ling, Liu and Wang.