MRI and amino acid PET detection of whole-brain tumor burden

Frontiers in Oncology

Oncology

Debbie R. Healey¹  C. Chad Quarles¹  Shwetal Mehta²  Matthew L. Scarpelli³  Peng Chen³ 

[1] Department of Cancer Systems Imaging, The University of Texas (UT) MD Anderson Cancer Center, Houston, TX, United States;Ivy Brain Tumor Center, Barrow Neurological Institute, Phoenix, AZ, United States;School of Health Sciences, Purdue University, West Lafayette, IN, United States;

关键词: MRI;    amino acid PET;    tissue clearing;    glioblastoma;    brain tumor;    imaging;   

DOI  :  10.3389/fonc.2023.1248249

 received in 2023-06-26, accepted in 2023-08-30,  发布年份 2023

来源: Frontiers

【 摘 要 】

Background[18F]fluciclovine amino acid PET has shown promise for detecting brain tumor regions undetected on conventional anatomic MRI scans. However, it remains unclear which of these modalities provides a better assessment of the whole brain tumor burden. This study quantifies the performance of [18F]fluciclovine PET and MRI for detecting the whole brain tumor burden.MethodsThirteen rats were orthotopically implanted with fluorescently transduced human glioblastoma cells. Rats underwent MRI (T1- and T2-weighted) and [18F]fluciclovine PET. Next brains were excised, optically cleared, and scanned ex vivo with fluorescence imaging. All images were co-registered using a novel landmark-based registration to enable a spatial comparison. The tumor burden identified on the fluorescent images was considered the ground truth for comparison with the in vivo imaging.ResultsAcross all cases, the PET sensitivity for detecting tumor burden (median 0.67) was not significantly different than MRI (combined T1+T2-weighted) sensitivity (median 0.61; p=0.85). However, the combined PET+MRI sensitivity (median 0.86) was significantly higher than MRI alone (41% higher; p=0.004) or PET alone (28% higher; p=0.0002). The specificity of combined PET+MRI (median=0.91) was significantly lower compared with MRI alone (6% lower; p=0.004) or PET alone (2% lower; p=0.002).ConclusionIn these glioblastoma xenografts, [18F]fluciclovine PET did not provide a significant increase in tumor burden detection relative to conventional anatomic MRI. However, a combined PET and MRI assessment did significantly improve detection sensitivity relative to either modality alone, suggesting potential value in a combined assessment for some tumors.

【 授权许可】

Unknown   
Copyright © 2023 Chen, Scarpelli, Healey, Mehta and Quarles