Serum liver fibrosis markers predict hepatic decompensation in compensated cirrhosis

BMC Gastroenterology

Research

Qingling Chen¹  Ping Han¹  Ling Mei¹  Xu Han²  Jun Wen²  Jia Li²  Lu Zhai²  Lili Zhao²  Rui Zhong³ 

[1] Clinical School of the Second People’s Hospital, Tianjin Medical University, Tianjin, China;Department of Gastroenterology and Hepatology, Tianjin Second People’s Hospital, No.7, Sudi South Road, Nankai District, 300192, Tianjin, China;Department of Gastroenterology and Hepatology, Tianjin Second People’s Hospital, No.7, Sudi South Road, Nankai District, 300192, Tianjin, China;Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin, China;

关键词: Biomarker;    Fibrosis;    Compensated cirrhosis;    Hepatic decompensation;    Prognosis;   

DOI  :  10.1186/s12876-023-02877-2

 received in 2023-03-12, accepted in 2023-07-10,  发布年份 2023

来源: Springer

【 摘 要 】

Background and aimThe literature is sparse on the association between serum liver fibrosis markers and the development of hepatic decompensation in patients with compensated cirrhosis. We aimed to assessed whether the serum liver fibrosis markers are predictive of the occurrence of hepatic decompensation.MethodsWe ascertained 688 cirrhotic patients with varying etiologies, between December 2015 to December 2019. Serum hyaluronic acid (HA), laminin (LN), collagen IV (CIV), and N-terminal propeptide of type III collagen (PIIINP) levels were measured at enrollment. All subjects were followed for at least 6 months for occurrence of hepatic decompensation. Cox proportional hazard regression models were used to estimate the hazard ratios (HRs) of hepatic decompensation during follow-up.ResultsDuring a median follow-up of 22.0 (13.0–32.0) months, decompensation occurred in 69 (10.0%) patients. Multivariate analysis indicated that higher LN (HR: 1.008, 95% confidence interval [CI]: 1.002–1.014, P = 0.011) and CIV (HR: 1.004, 95% CI: 1.001–1.007, P = 0.003) levels were independently associated with hepatic decompensation. Furthermore, patients in the tertile 2 and tertile 3 groups for CIV levels had HRs of 4.787 (1.419, 16.152) (P = 0.012) and 5.153 (1.508, 17.604) (P = 0.009), respectively, for occurrence of decompensation event compared with those in the tertile 1 group.ConclusionSerum liver fibrosis markers, particularly in CIV, appeared to be reliable biomarkers of disease progression and liver decompensation in patients with compensated cirrhosis with varying etiologies.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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