Correlation of the ultrasound thyroid imaging reporting and data system with cytology findings among patients in Uganda

Thyroid Research

Research

Robert Lukande¹  Hamdi Mohamed Isse²  Senai Goitom Sereke²  Samuel Bugeza²  Rita Nassanga²  Fualal Jane Odubu³ 

[1] Department of Pathology, College of Health Science, MakerereUniversity, Kampala, Uganda;Department of Radiology and Radiotherapy, College of Health Science, MakerereUniversity, Kampala, Uganda;Department of Surgery, College of Health Science, Makerere University, Kampala, Uganda;

关键词: TI-RADS;    Ultrasound;    Cytology;    Fine needle aspiration;    Thyroid nodule;    Thyroid cancer;   

DOI  :  10.1186/s13044-023-00169-1

 received in 2022-11-23, accepted in 2023-06-10,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundUltrasonography is a noninvasive modality for the initial assessment of thyroid nodules. The American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) has demonstrated good performance in differentiating malignant thyroid nodules. However, the combination of ACR TI-RADS categories and cytology has not been studied extensively, in Uganda. The study aims to correlate ACR TI-RADS with cytology among patients referred for US-guided fine-needle aspiration at Mulago National Referral Hospital.MethodsThis was a hospital-based cross-sectional study that recruited 132 patients with thyroid nodules. Spearman’s correlation was used to establish a relationship between TI-RADS and cytology findings. The diagnostic accuracy of TI-RADS was assessed using sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratios.ResultsOf 132 study participants, 90% (n = 117) were females, and the mean age was 41 ± 13 years. One hundred sixty-one thyroid nodules were analyzed. More than half of the thyroid nodules (54.7%, n = 87) were solid or almost solid, 96.9% (n = 154) were shaped wider than tall, 57.2% (n = 91) had smooth margins, 83.7% (n = 133) were hyperechoic or isoechoic, and 88.7% (n = 141) had no echogenic foci. TI-RADS 3 was the most common at 42.9% (n = 69). The proportions of malignancy for TI-RADS 4 and TI-RADS 5 were 73.3% and 85.7%, respectively. The correlation between ACR TI-RADS and the Bethesda system of thyroid classification scores was r = 0.577. The sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratios of ACR TI-RADS were 90.9%, 98.5%, 90%, 99.3%, 62.3, and 0.1, respectively.ConclusionWe found that ACR TI-RADS classification is an appropriate and noninvasive method for assessing thyroid nodules in routine practice. It can safely reduce the number of unnecessary fine-needle aspiration in a significant proportion of benign thyroid lesions. Thyroid nodules classified as TI-RADS 3 should be followed routinely. ACR TI-RADS should be standardized as the screening tool in resource-limited areas.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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