Thyroid Research | |
Correlation of the ultrasound thyroid imaging reporting and data system with cytology findings among patients in Uganda | |
Research | |
Robert Lukande1  Hamdi Mohamed Isse2  Senai Goitom Sereke2  Samuel Bugeza2  Rita Nassanga2  Fualal Jane Odubu3  | |
[1] Department of Pathology, College of Health Science, MakerereUniversity, Kampala, Uganda;Department of Radiology and Radiotherapy, College of Health Science, MakerereUniversity, Kampala, Uganda;Department of Surgery, College of Health Science, Makerere University, Kampala, Uganda; | |
关键词: TI-RADS; Ultrasound; Cytology; Fine needle aspiration; Thyroid nodule; Thyroid cancer; | |
DOI : 10.1186/s13044-023-00169-1 | |
received in 2022-11-23, accepted in 2023-06-10, 发布年份 2023 | |
来源: Springer | |
【 摘 要 】
BackgroundUltrasonography is a noninvasive modality for the initial assessment of thyroid nodules. The American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) has demonstrated good performance in differentiating malignant thyroid nodules. However, the combination of ACR TI-RADS categories and cytology has not been studied extensively, in Uganda. The study aims to correlate ACR TI-RADS with cytology among patients referred for US-guided fine-needle aspiration at Mulago National Referral Hospital.MethodsThis was a hospital-based cross-sectional study that recruited 132 patients with thyroid nodules. Spearman’s correlation was used to establish a relationship between TI-RADS and cytology findings. The diagnostic accuracy of TI-RADS was assessed using sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratios.ResultsOf 132 study participants, 90% (n = 117) were females, and the mean age was 41 ± 13 years. One hundred sixty-one thyroid nodules were analyzed. More than half of the thyroid nodules (54.7%, n = 87) were solid or almost solid, 96.9% (n = 154) were shaped wider than tall, 57.2% (n = 91) had smooth margins, 83.7% (n = 133) were hyperechoic or isoechoic, and 88.7% (n = 141) had no echogenic foci. TI-RADS 3 was the most common at 42.9% (n = 69). The proportions of malignancy for TI-RADS 4 and TI-RADS 5 were 73.3% and 85.7%, respectively. The correlation between ACR TI-RADS and the Bethesda system of thyroid classification scores was r = 0.577. The sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratios of ACR TI-RADS were 90.9%, 98.5%, 90%, 99.3%, 62.3, and 0.1, respectively.ConclusionWe found that ACR TI-RADS classification is an appropriate and noninvasive method for assessing thyroid nodules in routine practice. It can safely reduce the number of unnecessary fine-needle aspiration in a significant proportion of benign thyroid lesions. Thyroid nodules classified as TI-RADS 3 should be followed routinely. ACR TI-RADS should be standardized as the screening tool in resource-limited areas.
【 授权许可】
CC BY
© BioMed Central Ltd., part of Springer Nature 2023
【 预 览 】
Files | Size | Format | View |
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RO202310119483810ZK.pdf | 1298KB | download | |
Fig. 12 | 152KB | Image | download |
MediaObjects/41408_2023_912_MOESM1_ESM.pdf | 3821KB | download | |
MediaObjects/13100_2023_300_MOESM3_ESM.pdf | 5377KB | download | |
Fig. 3 | 684KB | Image | download |
【 图 表 】
Fig. 3
Fig. 12
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