A meta-analysis for vaccine protection rate of duck hepatitis a virus in mainland China in 2009–2021

BMC Veterinary Research

Research

Huiling Zhang¹  Daiqi Yang²  Siyu Zhou²  Lina Ye²  Tangjie Zhang²  Xingping Hong² 

[1] Health Pharmacy, 10013, New York, NY, USA;Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, 225009, Yangzhou, Jiangsu, China;Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, 225009, Yangzhou, Jiangsu, China;

关键词: Duck hepatitis a virus;    Meta-analysis;    Vaccine protection rate;    Mainland China;    Duck;   

DOI  :  10.1186/s12917-023-03744-8

 received in 2023-02-02, accepted in 2023-09-15,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundDuck hepatitis A virus (DHAV) is a single-stranded, positive-strand small RNA virus that causes a very high mortality rate in ducklings. The DHAV-3 subtype incidence rate has recently increased in China, causing great economic losses to the waterfowl breeding industry. We analyzed the protection rate of DHAV vaccines used in mainland China from 2009 to 2021 and evaluated the effectiveness of vaccine prevention and control to reduce the economic losses caused by DHAV to the waterfowl breeding industry. We screened five electronic research databases and obtained 14 studies and patents on the protection efficiency of DHAV-1 and DHAV-3 vaccines.ResultsMeta-analysis demonstrated that immunized ducklings produced higher antibody levels and had a significantly higher survival rate than non-immunized ducklings [relative risk (RR) = 12, 95% confidence interval (CI) 6–26, P < 0.01]. The age of the ducks and vaccine valence did not affect protection efficiency. Data source analysis of the vaccine protection rate demonstrated that the vaccines conferred immune protection for ducklings in both small-scale experiments and large-scale clinical conditions. The analysis results revealed that although the vaccines conferred protection, the immune protective effect differed between small-scale experimental conditions and large-scale clinical conditions. This might have been due to non-standard vaccination and environmental factors.ConclusionsDomestic DHAV vaccines can protect ducklings effectively. The subjects immunized (breeding ducks or ducklings) and vaccine valence had no effect on the protective effect. Both small-scale experiments and large-scale clinical conditions conferred immune protection on ducklings, but vaccine immunization under small-scale experimental conditions had slightly better protective effects than large-scale clinical immunization.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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