S100A6: molecular function and biomarker role

Biomarker Research

Review

Xin Kang¹  Yidian Wang¹  Xuewen Kang²  Fengguang Yang³ 

[1]Department of Joint Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shanxi, China

[2]Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, China

[3]The Second Clinical Medical College, Lanzhou University, Lanzhou, China

[4]Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China

[5]Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, China

[6]The Second Clinical Medical College, Lanzhou University, Lanzhou, China

[7]Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China

[8]The Orthopedics Department of the Second Hospital of Lanzhou University, 82 Cuiying Men, 730000, Lanzhou, Gansu Province, PR China

关键词: S100A6;    Biomarker;    Cytoskeleton;    Cellular stress response;    Cell differentiation;    Tumor;    Stem cells;   

DOI  :  10.1186/s40364-023-00515-3

 received in 2023-05-16, accepted in 2023-08-03,  发布年份 2023

来源: Springer

【 摘 要 】

S100A6 (also called calcyclin) is a Ca2+-binding protein that belongs to the S100 protein family. S100A6 has many functions related to the cytoskeleton, cell stress, proliferation, and differentiation. S100A6 also has many interacting proteins that are distributed in the cytoplasm, nucleus, cell membrane, and outside the cell. Almost all these proteins interact with S100A6 in a Ca2+-dependent manner, and some also have specific motifs responsible for binding to S100A6. The expression of S100A6 is regulated by several transcription factors (such as c-Myc, P53, NF-κB, USF, Nrf2, etc.). The expression level depends on the specific cell type and the transcription factors activated in specific physical and chemical environments, and is also related to histone acetylation, DNA methylation, and other epigenetic modifications. The differential expression of S100A6 in various diseases, and at different stages of those diseases, makes it a good biomarker for differential diagnosis and prognosis evaluation, as well as a potential therapeutic target. In this review, we mainly focus on the S100A6 ligand and its transcriptional regulation, molecular function (cytoskeleton, cell stress, cell differentiation), and role as a biomarker in human disease and stem cells.

【 授权许可】

CC BY   
© Yumed Inc. and BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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