Risk of diabetes in patients with sleep apnea: comparison of surgery versus CPAP in a long-term follow-up study

Journal of Otolaryngology - Head & Neck Surgery

Original Research Article

David Perez del Rey¹  Gema Hernandez Ibarburu¹  Irene Marbán Alvarez¹  Jose Maria Ignacio²  Marina Carrasco Llatas³  Peter Baptista⁴  Juan Carlos Casado Morente⁵  Laura Rodriguez Alcala⁶  Carlos O’Connor-Reina⁶  Guillermo Plaza⁷  María Teresa García Iriarte⁸ 

[1] Biomedical Informatics Group, Universidad Politécnica de Madrid, Madrid, Spain;Neumology Department, Hospital Quironsalud Marbella, Marbella, Spain;Otorhinolaryngology Department Hospital Dr Peset, Valencia, Spain;Otorhinolaryngology Department, Clínica Universitaria de Navarra, Pamplona, Spain;Otorhinolaryngology Department, Hospital Quironsalud Marbella, 29680, Marbella, Spain;Otorhinolaryngology Department, Hospital Quironsalud Marbella, 29680, Marbella, Spain;Otorhinolaryngology Department, Hospital Quironsalud Campo de Gibraltar, Palmones, Spain;Otorhinolaryngology Department, Hospital Universitario de Fuenlabrada, Universidad Rey Juan Carlos, Madrid, Spain;Otorhinolaryngology Department, Hospital Sanitas la Zarzuela, Madrid, Spain;Otorhinolaryngology Department, Hospital Virgen de Valme, Seville, Spain;

关键词: Sleep apnea;    Upper airway surgery;    Continuous positive airway pressure (CPAP);    Big data;    Survival;    Diabetes;   

DOI  :  10.1186/s40463-022-00616-3

 received in 2022-06-24, accepted in 2022-12-14,  发布年份 2022

来源: Springer

【 摘 要 】

This study aimed to obtain a comprehensive view of the risk of developing diabetes in patients with obstructive sleep apnea (OSA) and to compare this risk between patients receiving continuous positive airway pressure (CPAP) therapy versus upper airway surgery (UAS). We used local and the global-scale federated data research network TriNetX to obtain access to electronic medical records, including those for patients diagnosed with OSA, from health-care organizations (HCOs) worldwide. Using propensity score matching and the score-matched analyses of data for 5 years of follow-up, we found that patients who had undergone UAS had a lower risk of developing diabetes than those who used CPAP (risk ratio 0.415, 95% confidence interval (CI) 0.349–0.493). The risk for newly diagnosed diabetes patients showed a similar pattern (hazard ratio 0.382; 95% CI 0.317–0.459). Both therapies seem to protect against diabetes (Risk 0.081 after UAS vs. 0.195 after CPAP). Analysis of the large data sets collected from HCOs in Europe and globally lead us to conclude that, in patients with OSA, UAS can prevent the development of diabetes better than CPAP. Graphical Abstract

【 授权许可】

CC BY   
© Canadian Society Of Otolaryngology-Head & Neck Surgery 2023

【 图 表 】

Fig. 4

Fig. 5

Fig. 2

Fig. 3

Fig. 2