期刊论文详细信息
Cancer Imaging | |
Clinical application of Al18F-NOTA-FAPI PET/CT in diagnosis and TNM staging of pancreatic adenocarcinoma, compared to 18F-FDG | |
Research Article | |
Hongyue Zhao1  Shan Liu1  Changjiu Zhao1  Zhehao Lyu1  Wei Han1  Yan Wang1  Jin He1  Peng Fu1  Lin Tian2  Qi Zhang3  | |
[1]The Department of Nuclear Medicine, the First Affiliated Hospital of Harbin Medical University, Postal Street, Harbin, Heilongjiang Province, China | |
[2]The Department of Pathology, the First Affiliated Hospital of Harbin Medical University, Postal Street, Harbin, Heilongjiang Province, China | |
[3]The Department of Radiology, the First Affiliated Hospital of Harbin Medical University, Postal Street, Harbin, Heilongjiang Province, China | |
关键词: [18F]FDG; AlF-NOTA-FAPI; PET/CT; Pancreatic cancer; Staging; | |
DOI : 10.1186/s40644-023-00596-1 | |
received in 2023-05-01, accepted in 2023-07-26, 发布年份 2023 | |
来源: Springer | |
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【 摘 要 】
PurposeThis study aimed to investigate the ability of Al18F-NOTA-FAPI PET/CT to diagnose pancreatic carcinoma and tumor-associated inflammation with the comparison of 18F-FDG PET/CT.MethodsProspective analysis of Al18F-NOTA-FAPI PET/CT and 18F-FDG PET/CT scans of 31 patients from 05/2021 to 05/2022 were analyzed. Al18F-NOTA-FAPI imaging was performed in patients who had Ce-CT and FDG PET/CT and the diagnosis was still unclear. Follow-up histopathology or radiographic examination confirmed the findings. Radiotracer uptake, diagnostic performance, and TNM (tumor-node-metastasis) classifications were compared.ResultsA total of 31 patients with pancreatic carcinoma (all were adenocarcinoma) underwent Al18F-NOTA-FAPI-04 PET/CT, including 20 male and 11 female patients, with a mean age of 58.2 ± 8.5 years. FAPI-04 PET/CT imaging showed a higher value of SUVmax-15min/30min/60min, SUVmean-15min/30min/60min, TBR1, and TBR2 in pancreatic carcinoma than FDG (all P < 0.01). The mean level of Al18F-NOTA FAPI-04 uptake values of the pancreatic ductal adenocarcinoma was higher than that of pancreatitis in both SUVmax-30min (P < 0.01), SUVmean-30min (P < 0.05), SUVmax-60min (P < 0.01), and SUVmean-60min (P < 0.01). The FAPI △SUVmax-1, △SUVmax-2, and △SUVmean-2 uptake values of pancreatic carcinoma were higher than tumor-associated inflammation (all P < 0.01). TNM staging of 16/31 patients changed after Al18F-NOTA FAPI-04 PET/CT examination with all upstaging changes.ConclusionAl18F-NOTA-FAPI-04 PET/CT at 15 and 30 min also demonstrated an equivalent detection ability of pancreatic lesion to 18F-FDG PET/CT. Delayed-phase Al18F-NOTA-FAPI-04 PET/CT can help differentiate pancreatic carcinoma and tumor-associated inflammation. Al18F-NOTA FAPI-04 PET/CT also performed better than FDG PET/CT in TNM staging.Trial registrationChinese Clinical Trial Registry, ChiCTR2100051406. Registered 23 September 2021, https://www.chictr.org.cn/showproj.html?proj=133033【 授权许可】
CC BY
© International Cancer Imaging Society (ICIS) 2023
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