Temporal and spatial patterns of recurrence in oral squamous cell carcinoma, a single-center retrospective cohort study in China

BMC Oral Health

Research

Bincan Sun¹  Tianru Yang¹  Feiya Zhu¹  Chengwen Gan²  Kai Wang³  Mengxue Wang³  Yannan Wang⁴ 

[1] Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, 87 Xiangya Road, 410008, Changsha, Hunan, China;Research Center of Oral and Maxillofacial Tumor, Xiangya Hospital, Central South University, Changsha, China;Institute of Oral Cancer and Precancerous Lesions, Central South University, Changsha, China;Department of Oral and Maxillofacial Surgery, Hainan Provincial People’s Hospital, Haikou, Hainan, China;Department of Oral and Maxillofacial Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China;Department of Vascular and Plastic Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China;

关键词: Oral squamous cell carcinoma;    Recurrence interval;    Recurrence site;    Early recurrence;    Risk factor;    Prognosis;   

DOI  :  10.1186/s12903-023-03204-7

 received in 2022-11-12, accepted in 2023-07-05,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundOral squamous cell carcinoma (OSCC) is an invasive cancer with a high recurrence rate. Most clinical studies have focused on the prognosis of patients with OSCC, few have investigated the causes and interventions that affect the recurrence. Our study is to explore the temporal and spatial patterns of recurrence in OSCC.Methods234 OSCC patients with recurrence in our hospital and 64 OSCC patients with recurrence in TCGA database were included in the study. Log-rank test and Multivariate Cox Regression Analysis were used to determine whether there was a significant difference between each selected demographic or clinical factors and recurrence. The Kaplan–Meier method was used to plot survival curves for each recurrence interval.ResultsThe proportion of OSCC patients in clinical and TCGA with early recurrence was 93.6% and 84.4%, respectively. Age, chewing betel nut, previous radiotherapy, histopathological grading of the primary tumor (poorly differentiated), lymph node metastasis and postoperative infection were found to be associated with the timing of recurrence. It was found that tongue cancer has more regional recurrences, while buccal cancer is mostly local and loco-regional recurrences. The earlier the recurrence, the greater the possibility of local-regional recurrence and the worse the prognosis.ConclusionMost of recurrent OSCC patients present early recurrence (< 18 months) with poor prognosis, and early recurrence is more prone to local recurrence. Moreover, recurrence site is related with primary site of OSCC.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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