期刊论文详细信息
BMC Ophthalmology | |
Choroid vascular changes in hyperopic anisometropia amblyopia using SS-OCTA | |
Research | |
Yadi Zhang1  Liu Yang1  Xiaopeng Gu1  Yiwen Cao2  Dehai Zhu2  | |
[1]Department of Ophthalmology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, 100034, Beijing, China | |
[2]Department of Pediatric Ophthalmology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, 100034, Beijing, China | |
关键词: Amblyopia; Hyperopia; Anisometropia; OCTA; Choroid; Choroidal thickness; Choroidal capillary; Choroidal vascularity volume; Choroidal vascularity index; | |
DOI : 10.1186/s12886-023-03121-x | |
received in 2022-12-21, accepted in 2023-08-31, 发布年份 2023 | |
来源: Springer | |
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【 摘 要 】
PurposeTo observe and understand the structural changes in choroidal vessels in eyes with hyperopic anisometropic amblyopia using swept-source optical coherence tomography angiography (SS-OCTA).MethodsA total of 44 patients were enrolled in this study: 22 children with hyperopic anisometropic amblyopia and 22 age-matched controls. SS-OCTA was used to scan the 6*6 mm macular area of their eyes. The average choroidal thickness (CT) and choroidal capillary flow area (CC) in a 3 mm diameter area centered on the macular area were obtained. The choroidal vascularity volume (CVV) was automatically extracted and 3D reconstructed by inbuild software, and the three-dimensional choroidal vascularity index (3D-CVI) was calculated. The effect of amblyopia on the choroidal vessel structure was assessed using generalized linear estimating equations (GEEs) corrected for axial length, sex, age, and best-corrected visual acuity.ResultsThe CC was greater in amblyopic eyes than in fellow eyes (P = 0.014) but was not significantly different from that in control eyes (P = 0.963). After correcting for sex, age, axial length, and visual acuity using GEEs, the mean CT in the amblyopic eyes was greater than that in the fellow eyes (P = 0.030) but was not significantly different from that in the control eyes (P = 0.160). The 3D-CVI in amblyopic eyes was higher than that in control eyes (P = 0.038) but was not significantly different from that in fellow eyes (P = 0.407). The three-dimensional choroidal vascularity volume (3D-CVV) was higher in amblyopic eyes than in fellow eyes (P = 0.046) and control eyes (P = 0.023).ConclusionsWe found that eyes with hyperopic anisometropic amblyopia demonstrated higher CT, CC and 3D-CVV values than the contralateral eyes after correction, while the 3D-CVI was unchanged. Compared with control eyes, amblyopic eyes had higher 3D-CVV and 3D-CVI values but similar CT and CC values. Amblyopic eyes may have different choroidal vascular structures from fellow and control eyes.【 授权许可】
CC BY
© BioMed Central Ltd., part of Springer Nature 2023
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