Body mass index affects the association between plasma lipids and peripheral eosinophils in a general chinese population: a cross-sectional survey

Lipids in Health and Disease

Research

Lan Gao¹  Yu Gao²  Xin Li²  Weihong Bai²  Xiaocheng Wang³ 

[1] College of Basic Medicine, Shanxi University of Chinese Medicine, 030619, Jinzhong, Shanxi, China;Department of Otorhinolaryngology, Shanxi Provincial People’s Hospital Affiliated to Shanxi Medical University, No. 29 of Twin Towers Temple Street, 030012, Taiyuan, Shanxi, China;Department of Statistics, Shanxi Provincial People’s Hospital Affiliated to Shanxi Medical University, No. 29 of Twin Towers Temple Street, 030012, Taiyuan, Shanxi, China;

关键词: Plasma lipid;    Body mass index;    Peripheral blood eosinophil;   

DOI  :  10.1186/s12944-023-01909-w

 received in 2023-06-04, accepted in 2023-08-23,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundLipid metabolism affects type 2 immunity; however, the association between plasma lipids and eosinophilic inflammation in humans is uncertain. This study analysed the relationship between plasma lipids and peripheral eosinophils and whether patterns differ with different body mass indexes (BMI).MethodsA cross-sectional survey including 62,441 healthy participants recruited from a regular health screening programme was conducted. Participants were divided into normal weight, overweight and obese subgroups according to BMI.ResultsMultiple linear regression analysis revealed that elevated logarithmic-transformed eosinophil counts (log(EOS)) significantly correlated with high total cholesterol(TC), triglyceride(TG), low-density lipoprotein-cholesterol (LDL-C), and low high-density lipoprotein-cholesterol (HDL-C)levels in the overall population, as well as in men and women, while certain associations between peripheral blood eosinophil percentage and serum lipids varied by gender. These correlations existed across almost all BMI subgroups, and standardised β values decreased sequentially with increasing BMI. HDL-C had the most significant effect on eosinophils in obese women. Two-factor analysis of variance showed log(EOS) increased with higher BMI and hyperlipidemia whether in male or female and a synergistic effect exists of lipid levels (TG and LDL-C) and BMI in men.ConclusionsBlood eosinophil counts were correlated with blood lipid levels and modified by body mass index status. The effects of lipid levels and body mass index on blood eosinophil counts were synergistic. Therefore, lipid metabolism may be involved in systemic eosinophil inflammation.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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Fig. 2