Association of free-living diet composition with plasma lipoprotein(a) levels in healthy adults

Lipids in Health and Disease

Research

Rajasekhar Ramakrishnan¹  Nelsa Matienzo²  Gissette Reyes-Soffer²  Anastasiya Matveyenko²  Tiffany Thomas³  Kyungyeon Kim⁴  Heather Seid⁵ 

[1] Center for Biomathematics, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, N.Y, USA;Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, N.Y, USA;Department of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, N.Y, USA;Institute of Human Nutrition, Columbia University, New York, N.Y, USA;Irving Institute for Clinical and Translational Research, Columbia University, New York, N.Y, USA;

关键词: Lipoprotein(a);    Diet quality;    Dietary components;    Saturated fatty acids;    HEI;   

DOI  :  10.1186/s12944-023-01884-2

 received in 2023-05-24, accepted in 2023-07-27,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundLipoprotein (a) [Lp(a)] is an apoB100-containing lipoprotein with high levels being positively associated with atherosclerotic cardiovascular disease. Lp(a) levels are genetically determined. However, previous studies report a negative association between Lp(a) and saturated fatty acid intake. Currently, apoB100 lowering therapies are used to lower Lp(a) levels, and apheresis therapy is FDA approved for patients with extreme elevations of Lp(a). The current study analyzed the association of free-living diet components with plasma Lp(a) levels.MethodsDietary composition data was collected during screening visits for enrollment in previously completed lipid and lipoprotein metabolism studies at Columbia University Irving Medical Center via a standardized protocol by registered dietitians using 24 hour recalls. Data were analyzed with the Nutrition Data System for Research (Version 2018). Diet quality was calculated using the Healthy Eating Index (HEI) score. Fasting plasma Lp(a) levels were measured via an isoform-independent ELISA and apo(a) isoforms were measured using gel electrophoresis.ResultsWe enrolled 28 subjects [Black (n = 18); Hispanic (n = 7); White (n = 3)]. The mean age was 48.3 ± 12.5 years with 17 males. Median level of Lp(a) was 79.9 nmol/L (34.4–146.0) and it was negatively associated with absolute (grams/day) and relative (percent of total calories) intake of dietary saturated fatty acids (SFA) (R = -0.43, P = 0.02, SFA …(% CAL): R = -0.38, P = 0.04), palmitic acid intake (R = -0.38, P = 0.05), and stearic acid intake (R = -0.40, P = 0.03). Analyses of associations with HEI score when stratified based on Lp(a) levels > or ≤ 100 nmol/L revealed no significant associations with any of the constituent factors.ConclusionsUsing 24 hour recall, we confirm previous findings that Lp(a) levels are negatively associated with dietary saturated fatty acid intake. Additionally, Lp(a) levels are not related to diet quality, as assessed by the HEI score. The mechanisms underlying the relationship of SFA with Lp(a) require further investigation.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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