NORMAN guidance on suspect and non-target screening in environmental monitoring

Environmental Sciences Europe

Review

Anne Togola¹  Randolph R. Singh²  Jeroen Meijer³  Marja Lamoree³  Frederic Béen⁴  Lutz Ahrens⁵  Alberto Celma⁵  Teresa Steininger-Mairinger⁶  Peter Haglund⁷  Katrin Vorkamp⁸  Linyan Zhu⁸  Martin Hansen⁸  Anneli Kruve⁹  Juliane Hollender^1,10  Jaroslav Slobodnik^1,11  Nikiforos Alygizakis^1,12  Lubertus Bijlsma^1,13  Martin Krauss^1,14  Qiuguo Fu^1,14  Tobias Schulze^1,14  Sylvain Merel^1,15  Christelle Margoum^1,15  Emmanuelle Vulliet^1,16  Aurelie Fildier^1,16  Ruben Gil-Solsona^1,17  Pablo Gago-Ferrero^1,17  Nikolaos S. Thomaidis^1,18  Emma L. Schymanski^1,19  Andrea M. Brunner^2,20  Pawel Rostkowski^2,21  Bastian Schulze^2,22  Cassandra Rauert^2,22  Sarit Kaserzon^2,22  Saer Samanipour^2,23 

[1] BRGM, 3 Avenue Claude Guillemin, 45060, Orléans, France;Chemical Contamination of Marine Ecosystems Unit, French Research Institute for the Exploitation of the Sea, Nantes, France;Chemistry for Environment and Health, Amsterdam Institute for Life and Environment (A-LIFE), Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands;Chemistry for Environment and Health, Amsterdam Institute for Life and Environment (A-LIFE), Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands;KWR Water Research Institute, Groningenhaven 7, 3430BB, Nieuwegein, The Netherlands;Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences (SLU), P. O. Box 7050, 750 07, Uppsala, Sweden;Department of Chemistry, Institute of Analytical Chemistry, University of Natural Resources and Life Sciences (BOKU), Muthgasse 18, 1190, Vienna, Austria;Department of Chemistry, Umeå University, 901 87, Umeå, Sweden;Department of Environmental Science, Aarhus University, Frederiksborgvej 399, 4000, Roskilde, Denmark;Department of Environmental Science, Stockholm University, Svante Arrhenius Väg 16, 114 18, Stockholm, Sweden;Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600, Dübendorf, Switzerland;Institute of Biogeochemistry and Pollutant Dynamics, ETH Zurich, 8092, Zurich, Switzerland;Environmental Institute, Okružná 784/42, 97241, Koš, Slovak Republic;Environmental Institute, Okružná 784/42, 97241, Koš, Slovak Republic;Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771, Athens, Greece;Environmental and Public Health Analytical Chemistry, Research Institute for Pesticides and Water, University Jaume I, Avda Sos Baynat S/N, 12071, Castellón, Spain;Helmholtz Centre for Environmental Research, UFZ, Permoserstr. 15, 04318, Leipzig, Germany;INRAE, UR RiverLy, 69625, Villeurbanne, France;Institut Des Sciences Analytiques, Univ Lyon, CNRS, Université Claude Bernard Lyon 1, Villeurbanne, France;Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Carrer Jordi Girona 18-26, 08034, Barcelona, Spain;Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771, Athens, Greece;Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 6 Avenue du Swing, 4367, Belvaux, Luxembourg;TNO Environmental Modelling Sensing and Analysis, Energy and Materials Transition Unit, Princetonlaan 6-8, 3584 CB, Utrecht, The Netherlands;The Climate and Environmental Research Institute NILU, Instituttveien 18, 2007, Kjeller, Norway;The University of Queensland, Queensland Alliance for Environmental Health Sciences (QAEHS), 20 Cornwall Street, 4102, Woolloongabba, QLD, Australia;Van’t Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Amsterdam, The Netherlands;

关键词: Non-target screening;    Suspect screening;    High-resolution mass spectrometry;    Sample preparation;    Organic contaminants;    Chromatography;    Ion mobility;    Data processing;    Quality assurance and control;    FAIR data management;   

DOI  :  10.1186/s12302-023-00779-4

 received in 2023-06-16, accepted in 2023-08-12,  发布年份 2023

来源: Springer

【 摘 要 】

Increasing production and use of chemicals and awareness of their impact on ecosystems and humans has led to large interest for broadening the knowledge on the chemical status of the environment and human health by suspect and non-target screening (NTS). To facilitate effective implementation of NTS in scientific, commercial and governmental laboratories, as well as acceptance by managers, regulators and risk assessors, more harmonisation in NTS is required. To address this, NORMAN Association members involved in NTS activities have prepared this guidance document, based on the current state of knowledge. The document is intended to provide guidance on performing high quality NTS studies and data interpretation while increasing awareness of the promise but also pitfalls and challenges associated with these techniques. Guidance is provided for all steps; from sampling and sample preparation to analysis by chromatography (liquid and gas—LC and GC) coupled via various ionisation techniques to high-resolution tandem mass spectrometry (HRMS/MS), through to data evaluation and reporting in the context of NTS. Although most experience within the NORMAN network still involves water analysis of polar compounds using LC–HRMS/MS, other matrices (sediment, soil, biota, dust, air) and instrumentation (GC, ion mobility) are covered, reflecting the rapid development and extension of the field. Due to the ongoing developments, the different questions addressed with NTS and manifold techniques in use, NORMAN members feel that no standard operation process can be provided at this stage. However, appropriate analytical methods, data processing techniques and databases commonly compiled in NTS workflows are introduced, their limitations are discussed and recommendations for different cases are provided. Proper quality assurance, quantification without reference standards and reporting results with clear confidence of identification assignment complete the guidance together with a glossary of definitions. The NORMAN community greatly supports the sharing of experiences and data via open science and hopes that this guideline supports this effort.

【 授权许可】

CC BY   
© Springer-Verlag GmbH Germany, part of Springer Nature 2023

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