Successful treatment of multidrug-resistant Pseudomonas aeruginosa keratitis with meropenem eye drops — a case report

Journal of Ophthalmic Inflammation and Infection

Research

Christian Maximilian Wertheimer¹  Armin Wolf¹  Carolin Elhardt¹ 

[1] Department of Ophthalmology, University Hospital Ulm, Prittwitzstrasse 43, 89075, Ulm, Germany;

关键词: Pseudomonas aeruginosa;    Keratitis;    Meropenem;    Multi-resistance;    Antibiotics;    Case report;   

DOI  :  10.1186/s12348-023-00363-0

 received in 2023-05-18, accepted in 2023-08-23,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThis case report describes the course and therapeutic management of a fast-spreading bacterial keratitis caused by multidrug-resistant (MDR) Pseudomonas aeruginosa (P. aeruginosa).Case presentationA 27-year-old male contact lens wearer presented with a multi-resistant, fast spreading P. aeruginosa keratitis. After initial resistance to various antibiotic therapies, testing revealed a MDR P. aeruginosa. The keratitis was treated successfully with specially prepared 50 mg/ml off-label meropenem eye drops for 18 days as well as systemic meropenem for seven days with rapid improvement of the corneal infiltrate.ConclusionThis case report demonstrates the combination of topical and systemic meropenem as a useful treatment option for corneal ulcers caused by MDR P. aeruginosa.

【 授权许可】

CC BY   
© Springer-Verlag GmbH Germany, part of Springer Nature 2023

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