Dietary total antioxidant capacity is associated with lower disease severity and inflammatory and oxidative stress biomarkers in patients with knee osteoarthritis

Journal of Health, Population and Nutrition

Research

Soudabeh Hamedi-Shahraki¹  Mehran Rahimlou²  Farshad Amirkhizi³ 

[1] Department of Epidemiology and Biostatistics, Faculty of Public Health, Zabol University of Medical Sciences, Zabol, Iran;Department of Nutrition, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran;Department of Nutrition, Faculty of Public Health, Zabol University of Medical Sciences, Zabol, Iran;

关键词: Osteoarthritis;    Antioxidant capacity;    Inflammation;    Food-frequency questionnaire;    Oxidative stress;   

DOI  :  10.1186/s41043-023-00450-x

 received in 2023-08-05, accepted in 2023-09-22,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThis study was designed to evaluate the association between dietary total antioxidant capacity and clinical and biochemical variables in patients with osteoarthritis.MethodsThis cross-sectional study was conducted among 160 patients with mild-to-moderate knee osteoarthritis. The Likert version of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC Index) was used to assess the severity of clinical symptoms in patients with knee osteoarthritis. The secondary outcomes included inflammatory and oxidative stress biomarkers. The participants' usual diets were assessed using a food frequency questionnaire (FFQ), and the dietary total antioxidant capacity (TAC) was calculated based on the ferric reducing antioxidant power method. Additionally, clinical and biochemical variables were evaluated using standard methods.ResultsThe mean age of the participants was 57.2 ± 8.1 years, and 55.6% of them were females. The dietary TAC scores in this study ranged from 3.67 to 24.72, with a mean of 12.05 ± 5.3. We found a significant inverse trend between the dietary TAC score and the total Western Ontario and McMaster Universities Osteoarthritis (WOMAC) score (P = 0.001), as well as the WOMAC stiffness (P = 0.008) and WOMAC physical function scores (P = 0.001). Furthermore, dietary TAC was inversely associated with serum concentrations of interleukin-6 (IL-6) (β = − 0.18, P = 0.020), tumor necrosis factor-α (TNF-α) (β = − 0.67, P < 0.001), matrix metalloproteinase-1 (MMP-1) (β = − 0.33, P < 0.001), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) (β = − 0.22, P = 0.005) levels.ConclusionThe results of this study demonstrate an inverse association between dietary total antioxidant capacity and clinical and biochemical variables in patients with osteoarthritis.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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