期刊论文详细信息
BMC Oral Health
A novel treatment based on powder jet deposition technique for dentin hypersensitivity: a randomized controlled trial
Research
Koji Ikeda1  Chie Kayaba1  Aki Kitaoka2  Hiroki Hihara2  Ryo Akatsuka3  Tetsuo Kawata4  Ryo Tagaino5  Kuniyuki Izumita6  Keiichi Sasaki7 
[1] Department of Development Promotion, Clinical Research, Innovation and Education Center, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan;Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, 4-1 Seiryo- machi, Aoba-ku, 980-8575, Sendai, Miyagi, Japan;Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, 4-1 Seiryo- machi, Aoba-ku, 980-8575, Sendai, Miyagi, Japan;Akatsuka Dental Clinic, 2838-1 Mawatari, 312-0012, Hitachinaka, Ibaraki, Japan;Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, 4-1 Seiryo- machi, Aoba-ku, 980-8575, Sendai, Miyagi, Japan;Otemachi Kawata Dental Clinic, 6-19 Otemachi, Aoba-ku, 980-0805, Sendai, Miyagi, Japan;Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aobaku, 980-8575, Sendai, Miyagi, Japan;Perioperative Oral Care Support, Tohoku University Hospital, 4-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Miyagi, Japan;Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Miyagi, Japan;
关键词: Hydroxyapatite;    Medical device;    Randomized control trial;    Translational study;    Biomaterial;   
DOI  :  10.1186/s12903-023-03431-y
 received in 2023-05-22, accepted in 2023-09-20,  发布年份 2023
来源: Springer
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【 摘 要 】

BackgroundThis study aimed to evaluate the efficacy and safety of dentin hypersensitivity (DH) treatment using a newly developed device based on a powder jet deposition (PJD) technique that creates a hydroxyapatite (HAP) layer on the dentin surface, thereby alleviating the hypersensitivity. The effect of the PJD treatment was compared with that of conventional treatment using Teethmate Desensitizer (TMD; calcium-phosphate containing material with TTCP (Ca4(PO4)2O) and DCPA (CaHPO4)), which has been used clinically in Japan with well-confirmed effectiveness.Materials and methodsA randomized controlled trial was conducted including 35 patients who had symptoms of DH in two or more quadrants. Two test teeth were selected per patient (70 teeth in total) and randomly assigned to PJD or TMD treatment. The efficacy was evaluated using the improvement rate for air and scratch pain according to the scores obtained via visual analog scale 12 weeks after treatment. The safety assessment was performed focusing on gingival index (GI) and spontaneous pain. The t-test was used to analyze the non-inferiority of PJD treatment compared to TMD treatment.ResultsThe improvement rate of air pain was 69.0% for PJD and 69.7% for TMD. The improvement rate of scratch pain was 80.8% for PJD and 81.7% for TMD. Non-inferiority with a margin of 10% was not observed for both air and scratch pain. No change was observed in GI from baseline and the improvement rate of spontaneous pain for PJD was higher than that for TMD.ConclusionNon-inferiority of PJD to TMD treatment was not observed in this study; however, it was not statistically demonstrated, and the results were thus interpreted as inconclusive. PJD did improve the DH symptoms, as did TMD. PJD’s therapeutic effect was most likely attributable to the deposition of a HAP layer on the tooth surface, which would alleviate hypersensitivity for at least 12 weeks without causing severe adverse events.Trial registrationUMIN-CTR. ID: UMIN000025022. date: 02/12/2016.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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