期刊论文详细信息
Chemical and Biological Technologies in Agriculture | |
Structural properties and immunomodulatory activity of an α-glucan purified from the fruiting body of Stropharia rugosoannulata | |
Research | |
Song Tingting1  Lv Guoying1  Zhang Zuofa1  Liu Jie1  Jin Qunli1  | |
[1]Institute of Horticulture, Zhejiang Academy of Agricultural Science, 310021, Hangzhou, China | |
关键词: Stropharia rugosoannulata; Structural properties; α--Glucan; Immunomodulatory activity; | |
DOI : 10.1186/s40538-023-00475-8 | |
received in 2023-07-28, accepted in 2023-09-17, 发布年份 2023 | |
来源: Springer | |
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【 摘 要 】
A novel polysaccharide PSRa-2 was purified from Stropharia rugosoannulata fruiting bodies using high pressure homogenization-assisted dual enzyme method, ion exchange, and gel chromatography. The PSRa-2 was characterized via FT-IR, HPAEC, SEM, Congo red test, SEC–MALLS-RI, methylation analysis, and NMR analysis. Structural characterization revealed that PSRa-2 was an α-glucan with a Mw 455.6 kDa. The backbone of PSRa-2 was composed of →4)-α-d-Glcp-(1→ and →3)-α-d-Glcp-(1→ and branches of α-d-Glcp-(1→ at position O-6 of →4,6)-α-d-Glcp-(1→. PSRa-2 induced splenocyte proliferation and protected splenocytes against 5-Fu-induced immunosuppression by restoring the proliferation and secretion of cytokines (TNF-α and IL-2) secretion levels. Thus, PSRa-2 exhibits obviously immunomodulatory activity and represents a potential natural immunomodulator.Graphical Abstract【 授权许可】
CC BY
© Springer Nature Switzerland AG 2023
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