Association between serum albumin levels and height loss in Japanese workers: a retrospective study

Journal of Physiological Anthropology

Original Article

Takeo Okada¹  Masahiko Kiyama¹  Hidenobu Hayakawa¹  Tetsuya Ohira²  Yuji Shimizu³  Eiko Honda³  Nagisa Sasaki³  Midori Takada³ 

[1] Department of Cardiovascular Disease Prevention, Osaka Center for Cancer and Cardiovascular Diseases Prevention, Osaka, Japan;Department of Epidemiology, Fukushima Medical University School of Medicine, Fukushima, Japan;Epidemiology Section, Division of Public Health, Osaka Institute of Public Health, Osaka, Japan;

关键词: Albumin;    Height loss;    Workers;    Retrospective;   

DOI  :  10.1186/s40101-023-00338-z

 received in 2023-02-07, accepted in 2023-09-04,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundHeight loss starting in middle age was previously shown to be associated with high cardiovascular mortality in later life. However, the factors associated with height loss remain unknown. Since low serum albumin levels are reported to be associated with high mortality caused by cardiovascular disease, they may also contribute to height loss.MethodsTo clarify the association between serum albumin and height loss, we conducted a retrospective study of 7637 Japanese workers who participated in general health check-ups from 2008 to 2019. Height loss was defined as the highest quartile of height loss per year.ResultsIndividual with high serum concentration of albumin possess beneficial influence on preventing incidence of height loss. In both men and women, serum albumin level was significantly inversely associated with height loss. After adjustment for known cardiovascular risk factors, the adjusted odd ratio (OR) and 95% confidence interval (CI) for height loss per 1 standard deviation of albumin (0.2 g/dL for both men and women) were 0.92 (0.86, 0.98) in men and 0.86 (0.79, 0.95) in women. Even when the analysis was limited to participants without hypoalbuminemia, essentially same association was observed, with fully adjusted corresponding ORs (95%CI) of 0.92 (0.86, 0.98) in men and 0.86 (0.78, 0.94) in women.ConclusionIndependent of known cardiovascular risk factors, higher serum albumin levels may prevent height loss among Japanese workers. While several different diseases cause hypoalbuminemia, they may not be the main reasons for the association between serum albumin and height loss. Though further research is necessary, this finding may help clarify the mechanisms underlying the association between height loss and higher mortality in later life.

【 授权许可】

CC BY   
© The Japan Society of Physiological Anthropology 2023

【 图 表 】

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